奥曲肽可防止 LPS 诱导的内皮细胞和肺损伤。

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2024-10-05 DOI:10.1016/j.cellsig.2024.111455

Saikat Fakir, Khadeja-Tul Kubra, Nektarios Barabutis

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引用次数: 0

摘要

生长激素（GH）是生长、细胞繁殖和再生的重要调节剂，受生长激素释放激素（GHRH）和体生长激素控制。脂多糖（LPS）会损害内皮功能，导致炎症和血管渗漏增加。奥曲肽 (OCT) 是一种经 FDA 批准的合成体生长抑素类似物 (SSA)，用于治疗肢端肥大症和神经内分泌肿瘤。本研究调查了 OCT 对牛和人肺内皮细胞以及小鼠肺内 LPS 诱导损伤的影响。我们的体外观察结果表明，OCT 能有效对抗 LPS 诱导的内皮渗漏、炎症和活性氧（ROS）生成。此外，OCT 还能降低急性肺损伤（ALI）实验模型中支气管肺泡灌洗液（BALF）的蛋白质浓度。我们的研究表明，OCT 可减轻 LPS 诱导的内皮细胞和肺损伤，这表明它可能是治疗与屏障功能障碍有关的疾病的一种令人兴奋的方法。

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Octreotide protects against LPS-induced endothelial cell and lung injury

Growth hormone (GH) is a crucial regulator of growth, cell reproduction, and regeneration; and it is controlled by growth hormone-releasing hormone (GHRH) and somatostatin. Lipopolysaccharides (LPS) can compromise endothelial function, leading to increased inflammation and vascular leak. Octreotide (OCT) is an FDA-approved synthetic somatostatin analog (SSA) used to treat acromegaly and neuroendocrine tumors. The present study investigates the effects of OCT on LPS-induced injury in bovine and human lung endothelial cells, as well as in mouse lungs. Our in vitro observations suggest that OCT effectively counteracts LPS-induced endothelial leak, inflammation, and reactive oxygen species (ROS) generation. Furthermore, OCT reduces bronchoalveolar lavage fluid (BALF) protein concentration in an experimental model of Acute Lung Injury (ALI). Our study suggests that OCT mitigates LPS-induced endothelial cell and lung injury, suggesting that it may represent an exciting therapeutic possibility in diseases related to barrier dysfunction.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.