作为脑肿瘤生物标志物的微小 RNA。

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Management and Research Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI:10.2147/CMAR.S484158

Wojciech Jelski, Barbara Mroczko

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引用次数: 0

摘要

多年来，脑肿瘤一直是致命的癌症，在大多数情况下，它们很难在早期阶段被诊断出来。因此，研究人员需要开发低成本、灵敏的癌症生物标志物检测方法。这类生物标志物包括 microRNA。各种体液中的 microRNA 表达与癌症有很高的相关性。多项研究表明，脑肿瘤患者脑脊液和血液样本中的 microRNA 表达发生了变化。新的生物标志物（如 microRNA）可能有助于在疾病初期诊断脑肿瘤，从而实现早期治疗并增加生存机会。这篇综述介绍了微RNA的诊断作用及其在脑肿瘤患者中用作生物标记物的前景。

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MicroRNAs as Biomarkers of Brain Tumor.

Brain tumors have been deadly cancers for years, and in most cases they are difficult to diagnose in their early stages. For this reason, researchers need to develop low-cost, sensitive methods for examining cancer biomarkers. Such biomarkers include microRNA. MicroRNA expression in various body fluids shows a high correlation with cancer. A number of studies have demonstrated changes in microRNA expression in cerebrospinal fluid and blood samples from patients with brain tumors. New biomarkers such as microRNAs may help diagnose brain tumors at the very beginning of the disease, enabling early treatment and increasing the chances of survival. This review describes the diagnostic role of microRNAs and the prospects for their use as biomarkers in patients with brain tumors.

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来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.