HFIP 作为合成间苯二酚[n]炔的多功能溶剂。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.211

Hormoz Khosravi, Valeria Stevens, Raúl Hernández Sánchez

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引用次数: 0

摘要

在此，我们将 1,1,1,3,3,3-hexafluorisopropanol (HFIP) 作为一种高效溶剂，用于在催化盐酸的存在下，在环境温度下几分钟内合成间苯二酚[n]炔。值得注意的是，文献中报道的在这种环化过程中最具挑战性的前驱体--具有抽电子基团和卤素的间苯二酚也可以被容忍。这种方法只需一个合成步骤就能得到各种 2-取代的间苯二酚[n]炔，分离产率高达 98%。

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HFIP as a versatile solvent in resorcin[n]arene synthesis.

Herein, we present 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as an efficient solvent for synthesizing resorcin[n]arenes in the presence of catalytic amounts of HCl at ambient temperature and within minutes. Remarkably, resorcinols with electron-withdrawing groups and halogens, which are reported in the literature as the most challenging precursors in this cyclization, are tolerated. This method leads to a variety of 2-substituted resorcin[n]arenes in a single synthetic step with isolated yields up to 98%.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.