一大批非综合征性色素性视网膜炎患者中的高反射神经节细胞层带:频率与临床相关性

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Margarida Q Dias, Nuno Gouveia, Maria Franca, Joaquim Murta, Rufino Silva, João Pedro Marques
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引用次数: 0

摘要

研究目的最近,光谱域光学相干断层扫描(SD-OCT)显示,部分色素性视网膜炎(RP)患者存在 "高反射神经节细胞层带"(HGB)。本研究旨在验证和描述 HGB 在一大批葡萄牙 RP 患者中的出现频率:这项单中心横断面队列研究纳入了经遗传学诊断为 RP 的连续患者。对 SD-OCT 图像进行审查,以确定是否存在 HGB 及其他视网膜合并症。HGB 被定义为神经节细胞层(GCL)厚度内的连续高反射带。我们建立了混合效应回归模型,考虑了眼间相关性,以研究预测视敏度的特征。随后,我们拟合了一个简化模型:结果:共纳入 201 名患者的 398 只眼睛。在 39 名患者(19.4%)的 69 只眼睛(17.3%)中发现了 HGB。出现 HGB 的患者在确诊时和症状出现时明显更年轻。有 HGB 眼的 BCVA [ETDRS (IQR)] 中位数为 65 (29) 个字母,无 HGB 眼的 BCVA 中位数为 70 (21) 个字母(P 结论:该研究验证了最近对 HGB 的描述:本研究验证了最近关于 RP 患者中 GCL 内 HGB 的描述。与没有 HGB 的眼睛相比,有 HGB 的眼睛 BCVA 明显较差,这表明 HGB 的存在可能是这些患者视力预后较差的 SD-OCT 生物标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyperreflective ganglion cell layer band in a large cohort of non-syndromic retinitis pigmentosa: Frequency and clinical correlations.

Purpose: Recently, an 'hyperreflective ganglion cell layer band' (HGB) has been described on spectral-domain optical coherence tomography (SD-OCT) in a subset of patients with retinitis pigmentosa (RP). This study aims to validate and describe the frequency of HGB in a large cohort of Portuguese patients with RP.

Methods: This single-centre, cross-sectional cohort study included consecutive patients with a genetic diagnosis of RP. SD-OCT images were reviewed to identify the presence of the HGB and other retinal comorbidities. The HGB was defined as a continuous hyperreflective band within the thickness of the ganglion cell layer (GCL). We built mixed-effects regression models, accounting for inter-eye correlations, to investigate features predictive of visual acuity. Subsequently, a reduced model was fitted.

Results: A total of 398 eyes from 201 patients were included. HGB was identified in 69 (17.3%) eyes from 39 (19.4%) patients. Patients presenting with the HGB were significantly younger at diagnosis and at symptom onset. Median BCVA [ETDRS (IQR)] was 65 (29) letters in eyes with the HGB and 70 (21) letters in eyes without HGB (p < 0.001). In both the full and reduced mixed-effects models, the presence of HGB and macular hole (MH) was significantly associated with worse BCVA.

Conclusions: This study validates the recent description of HGB within the GCL in a subset of patients with RP. Eyes with HGB demonstrated significantly worse BCVA compared to those without HGB, suggesting that the presence of HGB may serve as an SD-OCT biomarker of worse visual prognosis in these patients.

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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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