Ying Shen, Rongkai Cai, Liang Wu, Kun Han, Yu Yang, Dongsheng Mao
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引用次数: 0
摘要
随着 DNA 技术的飞速发展,智能 DNA 纳米反应器(iDNRs)已成为利用 DNA 结构多样性和可编程性的先进工具。由于其结构和功能的可编程性,iDNRs 在体内肿瘤诊断和治疗中发挥着重要而独特的作用。本综述概述了基于先进 DNA 技术的 iDNRs 结构设计方法,包括酶反应介导和无酶策略。本综述还重点介绍了 iDNRs 如何通过功能设计实现智能化,以及 iDNRs 在体内肿瘤诊断和治疗中的应用。总之,本综述总结了 iDNRs 技术的当前进展,讨论了存在的挑战,并提出了扩大其应用的未来方向,有望为体内肿瘤诊断和靶向治疗领域的发展提供启示。
Programmable Intelligent DNA Nanoreactors (iDNRs) for in vivo Tumor Diagnosis and Therapy.
With the rapid advancement of DNA technology, intelligent DNA nanoreactors (iDNRs) have emerged as sophisticated tools that harness the structural versatility and programmability of DNA. Due to their structural and functional programmability, iDNRs play an important and unique role in in vivo tumor diagnosis and therapy. This review provides an overview of the structural design methods for iDNRs based on advanced DNA technology, including enzymatic reaction-mediated and enzyme-free strategies. This review also focuses on how iDNRs achieve intelligence through functional design, as well as the applications of iDNRs for in vivo tumor diagnosis and therapy. In summary, this review summarizes current advances in iDNRs technology, discusses existing challenges, and proposes future directions for expanding their applications, which are expected to provide insights into the development of the field of in vivo tumor diagnostics and targeted therapies.
期刊介绍:
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
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