Yang Yu, Aiyan Shi, Tongtong Wang, Tiefeng Wang and Fei Xu
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引用次数: 0
摘要
高效检测手性分子对于满足药物检测、不对称合成等方面的手性分析需求非常重要。在此,我们开发了一种新方法来快速测定伯胺手性分子的浓度和构型。以醛官能化的酸碱敏感型氟烷染料(R-C)为活性剂,通过醛亚胺缩合反应与手性分子发生反应。混合操作完成后,检测到的手性分子的浓度和构型可分别从紫外-可见吸收光谱和 CD 光谱上轻松读取。
High-efficiency detection of primary amine-based chiral molecules by a facile aldimine condensation reaction†
Detection of chiral molecules in a high-efficiency way is very important to meet the demands for chiral analysis in drug testing, asymmetric synthesis, etc. Herein, we have developed a novel route to realize the rapid determination of concentration and configuration of primary amine-based chiral molecules. An aldehyde functionalized acid & base-sensitive fluorane dye (R–C) was used as the active agent to be reacted with the chiral molecules through an aldimine condensation reaction. After the mixing operation, concentration and configuration of the detected chiral molecule could be facilely read from the UV-vis absorption spectra and CD spectra, respectively.
期刊介绍:
An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.