在钴(II)催化下，通过无受体脱氢环化合成明确的包嘧啶衍生物。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-08 DOI:10.1039/d4ob01306a

Debjyoti Pal, Rajashri Sarmah, Avijit Mondal, Itu Mallick, Dipankar Srimani

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引用次数: 0

摘要

从医学科学到工业化学领域，包嘧啶分子的多功能性为研究人员提供了一个丰富的舞台。在此，我们首次介绍了通过无受体脱氢环化（ADA）共同催化合成 2,3-二氢-1H-哌啶的过程。除了具有不同官能度的苄醇外，杂芳基和脂肪醇也能提供良好的产率。我们的催化方案也适用于不同的脂肪醇，在保持远端不饱和度不变的情况下生成包嘧啶衍生物。为了了解反应顺序，我们进行了一些动力学和控制测试。

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Well-defined cobalt(II)-catalyzed synthesis of perimidine derivatives via acceptorless dehydrogenative annulation.

The versatility of the perimidine moiety offers a rich playground for researchers in fields ranging from medical science to industrial chemistry. Herein, we describe the first Co-catalyzed synthesis of 2,3-dihydro-1H-perimidine via acceptorless dehydrogenative annulation (ADA). Apart from featuring benzyl alcohol having different functionalities, heteroaryl and aliphatic alcohols also provide good yields. Our catalytic protocol is also suitable for different fatty alcohols for furnishing perimidine derivatives, keeping distal unsaturation intact. Several kinetic and control tests were carried out in order to understand the reaction sequence.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.