聚合诱导发光剂：活组织检查在精准医疗中的作用

IF 51.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Reviews Pub Date : 2024-10-08 DOI:10.1021/acs.chemrev.4c00244

Yanhong Duo, Lei Han, Yaoqiang Yang, Zhifeng Wang, Lirong Wang, Jingyi Chen, Zhongyuan Xiang, Juyoung Yoon, Guanghong Luo, Ben Zhong Tang

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引用次数: 0

摘要

活检（包括组织和液体活检）可为疾病的检测、诊断和监测提供全面、实时的生理和病理信息。基于荧光探针在活检中的优势，人们经常选择荧光探针来快速、微创地获取病理过程的充分信息。然而，人们发现传统的荧光探针具有聚集淬灭（ACQ）特性，阻碍了这一领域取得更大的进展。自从发现聚集诱导发射光源（AIEgen）以来，由于其独特的性能，包括高量子产率（QY）和信噪比（SNR）等，促进了分子仿生材料的快速发展。本综述旨在介绍基于 AIEgen 的生物荧光探针在真实或人工样本活检中的最新进展，以及这些 AIE 探针的关键特性。本综述分为：(i) 基于智能 AIEgens 的组织活检；(ii) 基于智能 AIEgens 的血液样本活检；(iii) 基于智能 AIEgens 的尿液样本活检；(iv) 基于智能 AIEgens 的唾液样本活检；(v) 基于智能 AIEgens 的其他液体样本活检；(vi) 展望与结论。这篇综述可为进一步探索各种智能 AIEgens 在精准医疗中的应用提供更多指导，激发人们的兴趣，促进更多创新想法的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

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Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological and pathological information for disease detection, diagnosis, and monitoring. Fluorescent probes are frequently selected to obtain adequate information on pathological processes in a rapid and minimally invasive manner based on their advantages for biopsy. However, conventional fluorescent probes have been found to show aggregation-caused quenching (ACQ) properties, impeding greater progresses in this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) have promoted rapid advancements in molecular bionanomaterials owing to their unique properties, including high quantum yield (QY) and signal-to-noise ratio (SNR), etc. This review seeks to present the latest advances in AIEgen-based biofluorescent probes for biopsy in real or artificial samples, and also the key properties of these AIE probes. This review is divided into: (i) tissue biopsy based on smart AIEgens, (ii) blood sample biopsy based on smart AIEgens, (iii) urine sample biopsy based on smart AIEgens, (iv) saliva sample biopsy based on smart AIEgens, (v) biopsy of other liquid samples based on smart AIEgens, and (vi) perspectives and conclusion. This review could provide additional guidance to motivate interest and bolster more innovative ideas for further exploring the applications of various smart AIEgens in precision medicine.

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来源期刊

Chemical Reviews 化学-化学综合

CiteScore

106.00

自引率

1.10%

发文量

278

审稿时长

4.3 months

期刊介绍： Chemical Reviews is a highly regarded and highest-ranked journal covering the general topic of chemistry. Its mission is to provide comprehensive, authoritative, critical, and readable reviews of important recent research in organic, inorganic, physical, analytical, theoretical, and biological chemistry. Since 1985, Chemical Reviews has also published periodic thematic issues that focus on a single theme or direction of emerging research.