可见光光氧化催化下的α-酮酸直接脱羧功能化

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-10-08 DOI:10.1021/acs.joc.4c02011

Huangbin Sun, Qianfan Zhang, Jie Tang, Xiaowen Chen, Guofang Jiang

{"title":"可见光光氧化催化下的α-酮酸直接脱羧功能化","authors":"Huangbin Sun, Qianfan Zhang, Jie Tang, Xiaowen Chen, Guofang Jiang","doi":"10.1021/acs.joc.4c02011","DOIUrl":null,"url":null,"abstract":"A novel and environmentally friendly photocatalytic strategy is presented for generating acyl radicals from benzoylformic acids, which are subsequently trapped by various sulfone-based SOMOphiles. This strategy provides a robust toolkit to access a variety of synthetically important functionalized aryl-ketone derivatives, which efficiently and directly construct acyl–S, acyl–Se, acyl–C, and acyl–N bonds. The broad substrate scope, excellent functional group compatibility, and mild reaction conditions make this protocol practical and attractive.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"4 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Visible-Light Photoredox-Catalyzed Direct Decarboxylative Functionalization of α-Keto Acids\",\"authors\":\"Huangbin Sun, Qianfan Zhang, Jie Tang, Xiaowen Chen, Guofang Jiang\",\"doi\":\"10.1021/acs.joc.4c02011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel and environmentally friendly photocatalytic strategy is presented for generating acyl radicals from benzoylformic acids, which are subsequently trapped by various sulfone-based SOMOphiles. This strategy provides a robust toolkit to access a variety of synthetically important functionalized aryl-ketone derivatives, which efficiently and directly construct acyl–S, acyl–Se, acyl–C, and acyl–N bonds. The broad substrate scope, excellent functional group compatibility, and mild reaction conditions make this protocol practical and attractive.\",\"PeriodicalId\":57,\"journal\":{\"name\":\"Journal of Organic Chemistry\",\"volume\":\"4 1\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Organic Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.joc.4c02011\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1021/acs.joc.4c02011","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

本文介绍了一种新型、环保的光催化策略，该策略可从苯甲酰甲酸中生成酰基自由基，这些自由基随后会被各种砜基 SOMOphiles 捕获。该策略提供了一个强大的工具包，可用于获得各种具有重要合成意义的官能化芳基酮衍生物，这些衍生物可高效、直接地构建酰基-S、酰基-Se、酰基-C 和酰基-N 键。广泛的底物范围、优异的官能团兼容性以及温和的反应条件使该方案实用且极具吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light Photoredox-Catalyzed Direct Decarboxylative Functionalization of α-Keto Acids

查看原文本刊更多论文

Visible-Light Photoredox-Catalyzed Direct Decarboxylative Functionalization of α-Keto Acids

A novel and environmentally friendly photocatalytic strategy is presented for generating acyl radicals from benzoylformic acids, which are subsequently trapped by various sulfone-based SOMOphiles. This strategy provides a robust toolkit to access a variety of synthetically important functionalized aryl-ketone derivatives, which efficiently and directly construct acyl–S, acyl–Se, acyl–C, and acyl–N bonds. The broad substrate scope, excellent functional group compatibility, and mild reaction conditions make this protocol practical and attractive.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.