回复：Paneth细胞中溶菌酶的表达不需要LRRK2

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-10-08 DOI:10.1038/s41590-024-01968-w

Chengye Zhang, Lizhuang Han, Kemeng Dong, Qin Zhang, Zhihua Liu

{"title":"回复：Paneth细胞中溶菌酶的表达不需要LRRK2","authors":"Chengye Zhang, Lizhuang Han, Kemeng Dong, Qin Zhang, Zhihua Liu","doi":"10.1038/s41590-024-01968-w","DOIUrl":null,"url":null,"abstract":"replying to A. Tasegian et al. Nature Immunology https://doi.org/10.1038/s41590-024-01972-0 (2024)We read the comments by Tasegian et al. related to our article published in Nature Immunology, entitled ‘Commensal bacteria direct selective cargo sorting to promote symbiosis’1, with keen interest. In Zhang et al.1, we reported a Nod2-LRRK2-dependent lysozyme-sorting phenomenon in Paneth cells. Tasegian et al.2 noted no change in lysozyme staining in Lrrk2−/− mice and the absence of leucine-rich repeat kinase 2 (LRRK2) on Paneth cell granules.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reply to: LRRK2 is not required for lysozyme expression in Paneth cells\",\"authors\":\"Chengye Zhang, Lizhuang Han, Kemeng Dong, Qin Zhang, Zhihua Liu\",\"doi\":\"10.1038/s41590-024-01968-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"replying to A. Tasegian et al. Nature Immunology https://doi.org/10.1038/s41590-024-01972-0 (2024)We read the comments by Tasegian et al. related to our article published in Nature Immunology, entitled ‘Commensal bacteria direct selective cargo sorting to promote symbiosis’1, with keen interest. In Zhang et al.1, we reported a Nod2-LRRK2-dependent lysozyme-sorting phenomenon in Paneth cells. Tasegian et al.2 noted no change in lysozyme staining in Lrrk2−/− mice and the absence of leucine-rich repeat kinase 2 (LRRK2) on Paneth cell granules.\",\"PeriodicalId\":19032,\"journal\":{\"name\":\"Nature Immunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":27.7000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41590-024-01968-w\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41590-024-01968-w","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

答复 A. Tasegian 等人：《自然-免疫学》https://doi.org/10.1038/s41590-024-01972-0 (2024)我们怀着浓厚的兴趣阅读了 Tasegian 等人对我们发表在《自然-免疫学》上的题为《共生细菌引导选择性货物分拣以促进共生》1 一文的评论。在 Zhang 等人1 的文章中，我们报道了在 Paneth 细胞中一种依赖 Nod2-LRRK2 的溶菌酶分选现象。Tasegian等人2注意到Lrrk2-/-小鼠的溶菌酶染色没有变化，而且Paneth细胞颗粒上没有富亮氨酸重复激酶2（LRRK2）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reply to: LRRK2 is not required for lysozyme expression in Paneth cells

查看原文本刊更多论文

Reply to: LRRK2 is not required for lysozyme expression in Paneth cells

replying to A. Tasegian et al. Nature Immunology https://doi.org/10.1038/s41590-024-01972-0 (2024)

We read the comments by Tasegian et al. related to our article published in Nature Immunology, entitled ‘Commensal bacteria direct selective cargo sorting to promote symbiosis’¹, with keen interest. In Zhang et al.¹, we reported a Nod2-LRRK2-dependent lysozyme-sorting phenomenon in Paneth cells. Tasegian et al.² noted no change in lysozyme staining in Lrrk2^−/− mice and the absence of leucine-rich repeat kinase 2 (LRRK2) on Paneth cell granules.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.