与胃肠道癌症发展有关的细菌小分子代谢物

IF 69.2 1区生物学 Q1 MICROBIOLOGY

Nature Reviews Microbiology Pub Date : 2024-10-07 DOI:10.1038/s41579-024-01103-4

Tayah Turocy, Jason M. Crawford

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引用次数: 0

摘要

癌症与人类微生物组的组成和功能之间存在许多关联。由于癌症仍然是全球第二大死亡原因，研究微生物组的致癌作用可以促进我们对癌症风险的了解，并支持潜在的治疗干预措施。虽然细菌种类的波动与癌症的进展有关，但研究它们的小分子代谢物为确定因果关系和宿主-微生物相互作用的分子机制提供了一个途径。在这篇综述中，我们将探讨不断扩大的小分子代谢物及其与胃肠道癌症发病风险有关的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bacterial small molecule metabolites implicated in gastrointestinal cancer development

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Bacterial small molecule metabolites implicated in gastrointestinal cancer development

Numerous associations have been identified between cancer and the composition and function of the human microbiome. As cancer remains the second leading global cause of mortality, investigating the carcinogenic contributions of microbiome members could advance our understanding of cancer risk and support potential therapeutic interventions. Although fluctuations in bacterial species have been associated with cancer progression, studying their small molecule metabolites offers one avenue to establish support for causal relationships and the molecular mechanisms governing host–microorganism interactions. In this Review, we explore the expanding repertoire of small molecule metabolites and their mechanisms implicated in the risk of developing gastrointestinal cancers.

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来源期刊

Nature Reviews Microbiology 生物-微生物学

CiteScore

74.00

自引率

0.50%

发文量

149

审稿时长

6-12 weeks

期刊介绍： At Nature Reviews Microbiology, our goal is to become the leading source of reviews and commentaries for the scientific community we cater to. We are dedicated to publishing articles that are not only authoritative but also easily accessible, supplementing them with clear and concise figures, tables, and other visual aids. Our objective is to offer an unparalleled service to authors, referees, and readers, and we continuously strive to maximize the usefulness and impact of each article we publish. With a focus on Reviews, Perspectives, and Comments spanning the entire field of microbiology, our wide scope ensures that the work we feature reaches the widest possible audience.