异丙孕酮和侵入性记忆：创伤后应激障碍治疗的潜在治疗靶点？

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2024-10-05 DOI:10.1016/j.pnpbp.2024.111168

Khalisa Amir Hamzah, Ottmar V. Lipp, Luke J. Ney

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引用次数: 0

摘要

在治疗创伤后应激障碍（PTSD）以及了解其恐惧和应激相关症状方面，已经投入了大量研究。然而，目前的干预措施仅对 60% 的患者有效。异丙孕酮对抑制性神经递质和生理应激反应有影响，因此已成为创伤后应激障碍的一个关注话题。本综述探讨了现有的文献，这些文献表明异丙孕酮对以下方面有影响：（a）慢性压力和焦虑样症状；（b）恐惧条件反射和情境性恐惧；以及（c）侵入性记忆和情绪记忆。研究表明，异孕酮与创伤后应激障碍之间存在关系，并推测异孕酮是治疗创伤后应激障碍的潜在靶点。这一令人兴奋的前景要求扩大对异孕酮与创伤后应激障碍之间直接关系的研究。

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Allopregnanolone and intrusive memories: A potential therapeutic target for PTSD treatment?

Significant amounts of research have been devoted to treatment of post-traumatic stress disorder (PTSD) and the understanding of its fear and stress-related symptoms. However, current interventions are only effective in 60 % of the patient population. Allopregnanolone has become a topic of interest for PTSD due to its influences on inhibitory neurotransmission and the physiological stress response. This review explores available literature that suggests that allopregnanolone has an influence on (a) chronic stress and anxiety-like symptoms, (b) fear conditioning and contextual fear, and (c) intrusive and emotional memories. A relationship between allopregnanolone and PTSD is suggested, postulating that allopregnanolone is a potential target for the treatment of PTSD. This very exciting prospect calls for the expansion of research investigating a direct relationship between allopregnanolone and PTSD.

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.