淋巴瘤患者感染 SARS-CoV-2 的结果及引发肺炎的风险因素。

IF 2.8 Q2 INFECTIOUS DISEASES
Hanter Hong, Su-Mi Choi, Yeong-Woo Jeon, Tong-Yoon Kim, Seohyun Kim, Tai Joon An, Jeong Uk Lim, Chan Kwon Park
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引用次数: 0

摘要

背景:尽管淋巴瘤患者似乎特别容易受到严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)感染,但淋巴恶性肿瘤患者冠状病毒病2019(COVID-19)的临床演变一直未得到充分报道,尤其是与化疗、化疗免疫疗法有关的情况:在一家拥有 500 张床位的大学附属医院淋巴瘤专科中心接受治疗的成年淋巴瘤患者中,我们回顾性地查阅了 2020 年 1 月至 2022 年 4 月期间确诊感染 SARS-CoV-2 的患者的病历:结果:共纳入 117 名患者,中位年龄为 53 岁。其中127例(95.7%)为非霍奇金淋巴瘤。86名患者(73.5%)正在接受积极化疗,9名患者处于干细胞移植后状态。61名患者患有一种以上的合并症,29名患者患有低丙种球蛋白血症。34名患者(29.1%)从未接种过COVID-19疫苗。在中位 134 天的随访期间,37 名患者(31.6%)发生了 COVID-19 肺炎。除去 3 名在 30 天前死亡的患者,34 名患者中有 31 人持续出现 COVID-19 症状。有 11 名患者(9.4%)在确诊 COVID-19 后 90 天仍有 COVID-19 后肺部症状。总死亡率为 10.3%(117 例中有 12 例),其中肺炎患者的死亡率较高。在多变量分析中,65岁或以上、滤泡性淋巴瘤、接受利妥昔单抗维持治疗和未接种疫苗与COVID-19肺炎的发生有显著相关性:结论:淋巴瘤患者在感染 SARS-CoV-2 后患肺炎的风险很高,且症状持续时间较长。对于因利妥昔单抗维持治疗和低丙种球蛋白血症而导致体液反应受损的淋巴瘤患者,需要采取更积极的疫苗接种和保护措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Outcome of SARS-CoV-2 Infection in Patients with Lymphoma and the Risk Factors for the Development of Pneumonia.

Background: Although patients with lymphoma appear particularly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the clinical evolution of coronavirus disease 2019 (COVID-19) in a patient with lymphoid malignancies has been under-represented, especially in relation to chemo-, chemo-immunotherapy.

Materials and methods: Among adult patients with lymphoma receiving treatment in a specialized lymphoma center at a 500-bed, university-affiliated hospital, we retrospectively reviewed the medical records of patients diagnosed with SARS-CoV-2 infection from January 2020 to April 2022.

Results: A total of 117 patients with a median age of 53 years were included. One hundred twelves (95.7%) were non-Hodgkin lymphoma. Eighty-six patients (73.5%) were on active chemotherapy and 9 were post stem cell transplant state. Sixty-one patients had more than one comorbidity and 29 had hypogammaglobulinemia. Thirty-four patients (29.1%) had never received a COVID-19 vaccine. During a median follow-up of 134 days, COVID-19 pneumonia developed in 37 patients (31.6%). Excluding three patients who died before the 30 days, 31 out of 34 patients had ongoing symptomatic COVID-19. Eleven patients (9.4%) had post COVID-19 lung condition that persisted 90 days after COVID-19 diagnosis. Overall mortality was 10.3% (12 of 117), which was higher in patients with pneumonia. In multivariate analyses, age 65 years or older, follicular lymphoma, receiving rituximab maintenance therapy, and lack of vaccination were significantly associated with the development of COVID-19 pneumonia.

Conclusion: Patients with lymphoma are at high risk for developing pneumonia after SARS-CoV-2 infection and suffer from prolonged symptoms. More aggressive vaccination and protective measures for patients with lymphoma who have impaired humoral response related to rituximab maintenance therapy and hypogammaglobulinemia are needed.

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来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
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