透视心脏低温氧合灌注过程中红血细胞的附加值。

IF 6.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Heart and Lung Transplantation Pub Date : 2024-10-05 DOI:10.1016/j.healun.2024.09.025

Mats T Vervoorn, Elisa M Ballan, Selma E Kaffka Genaamd Dengler, Veronique M F Meijborg, Saskia C A de Jager, Richard Van Wijk, Niels P van der Kaaij

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引用次数: 0

摘要

低温氧合灌注（HOPE）是一种新兴的供体心脏保存技术，目前正在多项临床试验中进行研究，结果令人鼓舞。与其他器官的 HOPE 相比，心脏方案涉及补充红细胞 (RBC)，尽管没有比较证据证明其益处。在本视角论文中，我们将讨论在心脏 HOPE 期间补充红细胞的利弊。尽管目前在 HOPE 期间补充 RBC 的临床效果似乎很好，但也不能排除补充 RBC 的潜在弊端。在心脏 HOPE 期间补充 RBC 的影响需要进一步研究，以改进 HOPE 方案，从而利用这一前景看好的技术优化心脏保存。

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A perspective on the added value of red blood cells during cardiac hypothermic oxygenated perfusion.

Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other organs, cardiac protocols involve red blood cell (RBC) supplementation, despite absence of comparative evidence for its benefits. In this perspective paper, we discuss the pros and cons of the addition of RBCs during cardiac HOPE. Although the current clinical results with RBC supplementation during HOPE seem promising, potential downsides of RBC supplementation cannot be ruled out. The impact of supplemented RBCs during cardiac HOPE requires further investigation to improve HOPE protocols, to optimize heart preservation using this promising technology.

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来源期刊

Journal of Heart and Lung Transplantation 医学-呼吸系统

CiteScore

10.10

自引率

6.70%

发文量

1667

审稿时长

69 days

期刊介绍： The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.