梅丁，血管病理学与痴呆症之间的联系？

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-10-07 DOI:10.1177/0271678X241289772

Ilse S Altenburg, Nina G Smets, Gustav J Strijkers, Erik Ntp Bakker

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引用次数: 0

摘要

Medin 是一种从牛奶脂肪球表皮生长因子 VIII（MFG-E8）中提取的蛋白质片段。大多数 50 岁以上的人血管壁中都存在 Medin 聚集。在这篇叙述性综述中，我们将重点关注髓磷脂聚集与痴呆症发展的关系。最近的文献显示，medin 是脑脊液中痴呆症的生物标志物，特别是血管亚型痴呆症。临床前研究表明，medin 与衰老相关的脑血管功能障碍、血管硬化、高血压和血管淀粉样蛋白 β 沉积有关。这些研究结果表明，medin 是衰老、血管病理学和痴呆症之间的潜在机理联系。

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Medin, a link between vascular pathology and dementia?

Medin is a protein fragment derived from milk fat globule epidermal growth factor VIII (MFG-E8). Medin aggregates are present in the vessel wall of most subjects over 50 years of age. In this narrative review, we focus on the consequences of medin aggregation in relation to the development of dementia. Recent literature revealed medin as biomarker for dementia in CSF, specifically of a vascular subtype. Preclinical work showed that medin is associated with aging-related cerebral vascular dysfunction, vascular stiffening, hypertension, and. vascular amyloid β deposition. These findings position medin as a potential mechanistic link between aging, vascular pathology and dementia.

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.