滋养细胞疾病和绒毛膜癌。

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso Pub Date : 2024-10-01 DOI:10.1016/j.ejso.2024.108727

Graziella Camilleri, Jean Calleja-Aguis, Edith Said

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引用次数: 0

摘要

妊娠滋养细胞疾病（GTD）是一组与妊娠滋养细胞发育异常有关的疾病。妊娠滋养细胞疾病包括水滴形痣（HM），它可能继续进一步发展为妊娠滋养细胞肿瘤（GTN），如绒毛膜癌（CC）。妊娠滋养细胞肿瘤是一种恶性肿块，可能源于HM、其他（正常）妊娠或其他妊娠事件（如宫外孕）。本综述旨在概述目前对 GTD 和妊娠 CC 遗传学和表观遗传学的了解，以及这两种疾病之间的联系。

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Trophoblastic disease and choriocarcinoma.

Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.

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来源期刊

Ejso 医学-外科

CiteScore

6.40

自引率

2.60%

发文量

1148

审稿时长

41 days

期刊介绍： JSO - European Journal of Surgical Oncology ("the Journal of Cancer Surgery") is the Official Journal of the European Society of Surgical Oncology and BASO ~ the Association for Cancer Surgery. The EJSO aims to advance surgical oncology research and practice through the publication of original research articles, review articles, editorials, debates and correspondence.