热休克蛋白 110：疾病诊断和靶向治疗的新候选者。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-10-04 DOI:10.1016/j.drudis.2024.104199

Congke Zhao , Honglin Xiang , Mengqi Li , Ruizhe Gao , Yifan Zhang , Qianbin Li , Liqing Hu

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引用次数: 0

摘要

真核生物中的热休克蛋白 110（Hsp110）家族在维持细胞蛋白稳态方面发挥着关键作用。作为一类独特的分子伴侣，Hsp110s 既是独立的伴侣，也是其他重要分子伴侣的辅助伴侣。许多疾病都与 Hsp110s 的功能失常有关。因此，以 Hsp110s 或其与客户蛋白的相互作用为靶点可能为开发治疗药物提供新的方法。在这篇综述中，我们描述了目前对 Hsp110s 在疾病发展中的作用和分子机制的理解，并讨论了最近对 Hsp110s 作为潜在靶点的探索，从而为疾病诊断和靶向治疗提供一个新的方向。

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Heat shock protein 110: A novel candidate for disease diagnosis and targeted therapy

The heat shock protein 110 (Hsp110) family in eukaryotes plays a pivotal role in maintaining cellular proteostasis. As a unique class of molecular chaperones, Hsp110s act as both independent chaperones and cochaperones for other essential molecular chaperones. Malfunction of Hsp110s is involved in many diseases. Thus targeting Hsp110s or its interactions with client proteins may provide new approaches for developing therapeutics. In this review, we describe the current understanding of the role and molecular mechanism of Hsp110s in disease development, and discuss the recent exploration of Hsp110s as potential targets to provide a novel direction for disease diagnosis and targeted therapy.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.