Joseph P Fiorellini, Sean Mojaver, George Kay, Yu Cheng Chang, Michael Brown, Hector Sarmiento
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An Organic Mineral Adhesive Bone Graft: A Preclinical Study.
Purpose: To evaluate four formulations of tetracalcium phosphate combined with phosphoserine (TTCP-PS) in comparison to the conventional grafting materials bioglass (BG) and deproteinized cancellous bovine bone with a bioresorbable collagen membrane in standardized defects created in the angle of the rat mandible.
Materials and methods: TTCP-PS is a synthetic, injectable, cohesive, self-setting, mineral-organic wet-field adhesive. Microcomputed tomography (microCT) and histomorphometry were used to evaluate bone replacement with each of these materials after in vivo residence of either 4 or 12 weeks.
Results: Specific TTCP-PS formulations can form bone comparable to conventional materials in an osteopromotive mechanism but with the advantage of having cohesive and adhesive properties.
Conclusions: This study showed the potential for TTCP-PS to be used as a viable candidate for bone grafting procedures.
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