减少碳水化合物的饮食可改善养老院高血糖老年人的血糖调节:SAGE 研究。

Camille Vandenberghe, Elisabelle Hardy, Marie Christine Morin, Valérie St-Pierre, Karine Groulx, Mélanie Fortier, Daniel Tessier, Paul Leclerc, Stephen C Cunnane
{"title":"减少碳水化合物的饮食可改善养老院高血糖老年人的血糖调节:SAGE 研究。","authors":"Camille Vandenberghe, Elisabelle Hardy, Marie Christine Morin, Valérie St-Pierre, Karine Groulx, Mélanie Fortier, Daniel Tessier, Paul Leclerc, Stephen C Cunnane","doi":"10.1139/apnm-2024-0277","DOIUrl":null,"url":null,"abstract":"<p><p>Poor glucose regulation associated with gradual insulin resistance is a significant risk factor in several age-related chronic diseases. An eating plan that promotes a lower carbohydrate intake may have a beneficial effect on glucose metabolism. This study aimed to evaluate how a diet reduced in carbohydrate by 32% (RCHO) over a 2 month period would influence the metabolic profile of older individuals (<i>N</i> = 24) living in a retirement home (RH). A continuous glucose monitor was used to measure blood glucose during four periods: the standard diet before (baseline) and after (washout) the intervention, during the 4 initial days of the RCHO diet (RCHO-early), and the final days of the 2 month intervention (RCHO-end). The blood metabolic profile was also measured (glucose, ketones, insulin, triglycerides, and cholesterol). RCHO intake decreased average blood glucose compared to the standard diet in hyperglycemic participants: RCHO-early 7.8 ± 1.0 vs 7.5 ± 1.1 mM (<i>p =</i> 0.012) and RCHO-end 7.8 ± 1.0 vs 7.0 ± 0.9 mM (<i>p =</i> 0.050). In the hyperglycemic participants, the percentage of time spent in hyperglycemia (>10.0 mM) decreased by 50% during the RCHO-early (<i>p =</i> 0.012) and by 66% at RCHO-end (<i>p</i>  <i>=</i> 0.021) compared to baseline. Glycated hemoglobin was significantly lower at RCHO-end in both hyperglycemic and normoglycemic participants compared to baseline (<i>p</i> < 0.008). Plasma ketones increased threefold in hyperglycemic participants at RCHO-end compared to baseline (<i>p</i> < 0.028). This study shows that an RCHO diet has metabolic health benefits in an older population and confirms its safety, tolerability, and acceptability in an RH (NCT06022094).</p>","PeriodicalId":93878,"journal":{"name":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","volume":" ","pages":"1-10"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study.\",\"authors\":\"Camille Vandenberghe, Elisabelle Hardy, Marie Christine Morin, Valérie St-Pierre, Karine Groulx, Mélanie Fortier, Daniel Tessier, Paul Leclerc, Stephen C Cunnane\",\"doi\":\"10.1139/apnm-2024-0277\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Poor glucose regulation associated with gradual insulin resistance is a significant risk factor in several age-related chronic diseases. An eating plan that promotes a lower carbohydrate intake may have a beneficial effect on glucose metabolism. This study aimed to evaluate how a diet reduced in carbohydrate by 32% (RCHO) over a 2 month period would influence the metabolic profile of older individuals (<i>N</i> = 24) living in a retirement home (RH). A continuous glucose monitor was used to measure blood glucose during four periods: the standard diet before (baseline) and after (washout) the intervention, during the 4 initial days of the RCHO diet (RCHO-early), and the final days of the 2 month intervention (RCHO-end). The blood metabolic profile was also measured (glucose, ketones, insulin, triglycerides, and cholesterol). RCHO intake decreased average blood glucose compared to the standard diet in hyperglycemic participants: RCHO-early 7.8 ± 1.0 vs 7.5 ± 1.1 mM (<i>p =</i> 0.012) and RCHO-end 7.8 ± 1.0 vs 7.0 ± 0.9 mM (<i>p =</i> 0.050). In the hyperglycemic participants, the percentage of time spent in hyperglycemia (>10.0 mM) decreased by 50% during the RCHO-early (<i>p =</i> 0.012) and by 66% at RCHO-end (<i>p</i>  <i>=</i> 0.021) compared to baseline. Glycated hemoglobin was significantly lower at RCHO-end in both hyperglycemic and normoglycemic participants compared to baseline (<i>p</i> < 0.008). Plasma ketones increased threefold in hyperglycemic participants at RCHO-end compared to baseline (<i>p</i> < 0.028). This study shows that an RCHO diet has metabolic health benefits in an older population and confirms its safety, tolerability, and acceptability in an RH (NCT06022094).</p>\",\"PeriodicalId\":93878,\"journal\":{\"name\":\"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme\",\"volume\":\" \",\"pages\":\"1-10\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1139/apnm-2024-0277\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1139/apnm-2024-0277","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/4 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

与胰岛素抵抗渐进相关的葡萄糖调节能力差是多种与年龄有关的慢性疾病的重要风险因素。减少碳水化合物摄入量的饮食计划可能会对葡萄糖代谢产生有益影响。本研究旨在评估在两个月内减少 32% 碳水化合物(RCHO)的饮食会如何影响住在养老院(RH)的老年人(24 人)的代谢状况。连续血糖监测仪用于测量四个时期的血糖:干预前(基线)和干预后(冲淡)的标准饮食、RCHO 饮食的最初 4 天(RCHO-早期)以及为期 2 个月的干预的最后几天(RCHO-末期)。此外,还测量了血液代谢概况(葡萄糖、酮体、胰岛素、甘油三酯和胆固醇)。与标准饮食相比,摄入RCHO可降低高血糖参与者的平均血糖:RCHO 早期 7.8 ± 1.0 vs 7.5 ± 1.1 mM(p = 0.012),RCHO 末期 7.8 ± 1.0 vs 7.0 ± 0.9 mM(p = 0.050)。在高血糖参与者中,与基线相比,RCHO 早期(p = 0.012)和 RCHO 末期(p = 0.021)处于高血糖状态(> 10.0 mM)的时间分别减少了 50%和 66%。与基线相比,高血糖和正常血糖参与者的糖化血红蛋白在 RCHO 结束时均显著降低(p < 0.008)。与基线相比,高血糖患者在 RCHO 结束时血浆酮体增加了 3 倍(p < 0.028)。这项研究表明,RCHO 饮食对老年人群的代谢健康有益,并证实了其在 RH 中的安全性、耐受性和可接受性。(NCT06022094)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study.

Poor glucose regulation associated with gradual insulin resistance is a significant risk factor in several age-related chronic diseases. An eating plan that promotes a lower carbohydrate intake may have a beneficial effect on glucose metabolism. This study aimed to evaluate how a diet reduced in carbohydrate by 32% (RCHO) over a 2 month period would influence the metabolic profile of older individuals (N = 24) living in a retirement home (RH). A continuous glucose monitor was used to measure blood glucose during four periods: the standard diet before (baseline) and after (washout) the intervention, during the 4 initial days of the RCHO diet (RCHO-early), and the final days of the 2 month intervention (RCHO-end). The blood metabolic profile was also measured (glucose, ketones, insulin, triglycerides, and cholesterol). RCHO intake decreased average blood glucose compared to the standard diet in hyperglycemic participants: RCHO-early 7.8 ± 1.0 vs 7.5 ± 1.1 mM (p = 0.012) and RCHO-end 7.8 ± 1.0 vs 7.0 ± 0.9 mM (p = 0.050). In the hyperglycemic participants, the percentage of time spent in hyperglycemia (>10.0 mM) decreased by 50% during the RCHO-early (p = 0.012) and by 66% at RCHO-end (p  = 0.021) compared to baseline. Glycated hemoglobin was significantly lower at RCHO-end in both hyperglycemic and normoglycemic participants compared to baseline (p < 0.008). Plasma ketones increased threefold in hyperglycemic participants at RCHO-end compared to baseline (p < 0.028). This study shows that an RCHO diet has metabolic health benefits in an older population and confirms its safety, tolerability, and acceptability in an RH (NCT06022094).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信