帕金森病小脑足部微结构完整性的时间演变：特定阶段的模式和多巴胺能相关性。

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2024-01-01 DOI:10.1016/j.nicl.2024.103679

Chentao He , Rui Yang , Siming Rong , Piao Zhang , Xi Chen , Qi Qi , Ziqi Gao , Yan Li , Hao Li , Frank-Erik de Leeuw , Anil M. Tuladhar , Marco Duering , Rick C. Helmich , Rick van der Vliet , Sirwan K.L. Darweesh , Zaiyi Liu , Lijuan Wang , Mengfei Cai , Yuhu Zhang

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引用次数: 0

摘要

背景：先前的研究显示，不同疾病阶段的小脑白质完整性存在差异，这表明帕金森病（PD）具有代偿作用。然而，帕金森病患者（PwPD）小脑白质微结构的时间演变仍不清楚：揭示帕金森病小脑白质的时间演变及其多巴胺能相关性：我们从 PPMI 研究中招募了 124 名 PwPD 患者。参与者被分为两个子集：子集 1（n = 41）有三次 MRI 扫描（基线、2 年和 4 年），子集 2（n = 106）在基线、1 年和/或 2 年至少有两次 MRI 扫描。自由水校正扩散指标用于测量连接小脑和小脑的主要白质束--小脑梗（CP）的微观结构完整性。ACAPULCO 处理管道用于评估小脑小叶体积。线性混合效应模型用于研究纵向变化。我们还研究了CP微结构完整性、纹状体多巴胺转运体特异性结合率（SBR）和临床症状之间的关系：结果：CP 的微结构变化在 PwPD 中呈现非线性模式。自由水校正分数各向异性（FAt）在头两年有所增加，但在 2 至 4 年间有所下降，而自由水校正平均扩散率则呈现出相反的趋势。CP最初增加的FAt与小脑区域体积萎缩、纹状体多巴胺能SBR下降和临床症状恶化相关，但这种相关性在不同疾病阶段有所不同：我们的研究结果表明，CP的微结构完整性在整个帕金森病病程中呈非线性演变，这表明在帕金森病纹状体多巴胺能进行性退化的同时，小脑也在进行适应性结构重组。

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Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson’s disease: Stage-specific patterns and dopaminergic correlates

Background

Previous research revealed differences in cerebellar white matter integrity by disease stages, indicating a compensatory role in Parkinson’s disease (PD). However, the temporal evolution of cerebellar white matter microstructure in patients with PD (PwPD) remains unclear.

Objective

To unravel temporal evolution of cerebellar white matter and its dopaminergic correlates in PD.

Methods

We recruited 124 PwPD from the PPMI study. The participants were divided into two subsets: Subset 1 (n = 41) had three MRI scans (baseline, 2 years, and 4 years), and Subset 2 (n = 106) had at least two MRI scans at baseline, 1 year, and/or 2 years. Free water-corrected diffusion metrics were used to measure the microstructural integrity in cerebellar peduncles (CP), the main white matter tracts connecting to and from the cerebellum. The ACAPULCO processing pipeline was used to assess cerebellar lobules volumes. Linear mixed-effect models were used to study longitudinal changes. We also examined the relationships between microstructural integrity in CP, striatal dopamine transporter specific binding ratio (SBR), and clinical symptoms.

Results

Microstructural changes in CP showed a non-linear pattern in PwPD. Free water-corrected fractional anisotropy (FAt) increased in the first two years but declined from 2 to 4 years, while free water-corrected mean diffusivity exhibited the opposite trend. The initial increased FAt in CP correlated with cerebellar regional volume atrophy, striatal dopaminergic SBR decline, and worsening clinical symptoms, but this correlation varied across disease stages.

Conclusions

Our findings suggest a non-linear evolution of microstructural integrity in CP throughout the course of PD, indicating the adaptive structural reorganization of the cerebellum simultaneously with progressive striatal dopaminergic degeneration in PD.

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.