来自马里亚纳海沟的真菌 Talaromyces sp. SY2250 的新型代谢物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-10-04 DOI:10.1080/14786419.2024.2412305

Xin Liu, Mingzhu Ma, Yura Ha, Nan Wang, Yufang Zhou, Zhizhen Zhang

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引用次数: 0

摘要

从马里亚纳海沟沉积物衍生真菌塔拉霉菌（Talaromyces sp. SY2250）产生的代谢物中分离出了四个以前未曾描述过的化合物塔拉酯A（1）和紫酯C-E（2-4），以及已知的紫酯A（5）和紫内酯G（6）。化合物 2-5 是两对外消旋体，在手性高效液相色谱柱上进行了分离。根据 HRESIMS 数据、大量核磁共振光谱分析和旋光计算，确定了分离化合物的结构。Purpuride G（6）对胶质瘤细胞具有抗增殖活性，可能是塔拉酵母菌 SY2250 在水稻培养基中培养出的粗提取物中具有活性的主要化合物。

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Novel metabolites from the Mariana Trench-derived fungus Talaromyces sp. SY2250.

Four previously undescribed compounds talaromyester A (1) and purpuresters C-E (2-4), together with known purpurester A (5) and purpuride G (6), were isolated from the metabolites produced by the Mariana Trench sediment-derived fungus Talaromyces sp. SY2250. Compounds 2-5, two pairs of racemates, were separated on a chiral HPLC column. Structures of the isolated compounds were determined based on their HRESIMS data, extensive NMR spectroscopic analyses, and optical rotation calculations. Purpuride G (6) showed antiproliferative activity against glioma cells and may be the main active compound responsible for the activity of the crude extract prepared from the culture of Talaromyces sp. SY2250 in rice medium.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.