GD2和GD3神经节苷脂作为高级别浆液性卵巢癌的预后生物标志物

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of gynecology obstetrics and human reproduction Pub Date : 2024-10-03 DOI:10.1016/j.jogoh.2024.102860

Gabriel Levin , Emad Matanes , Amber Yasmeen , Raanan Meyer , Melica Nourmoussavi Brodeur , Shannon Salvador , Susie Lau , H. Uri Saragovi , Walter Gotlieb

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引用次数: 0

摘要

目的：神经节苷脂 GD2 和 GD3神经节苷脂 GD2 和 GD3 被认为对卵巢肿块的诊断具有重要意义。我们旨在研究血清GD2和GD3神经节苷脂作为高级别浆液性（HGS）卵巢癌（OC）肿瘤预后的预测因子：一项回顾性研究，包括2005-2016年间接受治疗的HGS OC的生物库血清样本。采用间接酶联免疫吸附法对血清中 GD2 和 GD3 的浓度进行量化，并分析其与生存率的关系：结果：共纳入 60 例患者。与较低水平的患者相比，GD3>12.8ng/mL的患者的PFS较短；中位31个月对67个月，P =.005。GD2>7.1ng/mL患者的中位生存期比低水平患者短（23个月对52个月，P =.024）。GD3>14.5ng/mL患者的OS比低水平患者短（中位31个月对70个月，P =.002）。在Cox回归中，在调整年龄、CA-125、疾病分期和年龄后，血清GD3升高与PFS缩短独立相关（调整后危险比2.0，95% CI 1.1-3.8，p=.024）。在单独的 Cox 回归中，GD2 升高与 PFS 独立相关（调整后危险比为 3.0（1.2-7.7），p=.019）。高血清GD3和GD2也与短OS独立相关：结论：HGS OC中血清GD2和GD3的高水平与较短的PFS和OS相关。作为预后的生物标志物，GD3优于GD2。

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GD2 and GD3 gangliosides as prognostic biomarkers in high grade serous ovarian cancer

Objective

Gangliosides GD2 and GD3 have been proposed to be of significance in diagnosis of ovarian masses. We aim to study serum GD2 and GD3 gangliosides as predictors of oncological outcomes among high grade serous (HGS) ovarian cancer (OC).

Materials and methods

A retrospective study including biobanked serum samples of HGS OC treated between 2005 and 2016. Serum GD2 and GD3 concentrations were quantified using indirect ELISA and analyzed with respect to survival.

Results

Sixty patients were included. Patients with GD3>12.8 ng/mL had shorter PFS when compared to patients with lower level; median 31 vs. 67 months, p = 0.005. Patients with GD2> 7.1 ng/mL had shorter median PFS than those with lower level of (23 vs. 52 months, p = 0.024.) Patients with GD3>14.5 ng/mL had shorter OS vs. patients with lower level (median 31 vs. 70 months, p = 0.002). In a Cox regression, following adjustment for age, CA-125, disease stage and age, serum elevated GD3 was independently associated with short PFS (adjusted hazard ratio 2.0, 95 % CI 1.1–3.8, p=.024). In a separate Cox regression, elevated GD2 was independently associated with PFS (adjusted hazard ratio3.0 (1.2–7.7). p=.019. High serum GD3 and GD2 were independently associated with short OS as well.

Conclusions

High levels of serum GD2 and GD3 in HGS OC were associated with shorter PFS and OS. GD3 is superior to GD2 as a biomarker for prognosis.

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来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.