发育过程中的体重指数与青少年毛发皮质醇:持续性、可变性和暴露时间的作用。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Christina Y Cantave, Paula L Ruttle, Sylvana M Coté, Sonia J Lupien, Marie-Claude Geoffroy, Frank Vitaro, Mara Brendgen, Richard Tremblay, Michel Boivin, Isabelle Ouellet-Morin
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引用次数: 0

摘要

背景:研究表明,糖皮质激素中的应激激素皮质醇可能在脂肪的积累过程中发挥了作用。然而,肥胖和体重波动也可能磨损促进适应的生理系统,影响皮质醇的分泌。在纵向研究中,对这种可能性的调查仍然很少。本研究测试了生命最初 15 年的体重指数(BMI)轨迹是否与两年后测量的毛发皮质醇浓度(HCC)相关,以及体重指数的变化和时间是否重要:方法:对 5 个月至 15 岁期间的 12 次体重指数(kg/m2)进行了前瞻性测量。对 565 名参与者 17 岁时的头发进行了采样。性别、家庭社会经济状况以及与 HCC 同时测量的 BMI 均被视为控制变量:潜类分析确定了三种 BMI 轨迹:结果:潜类分析确定了三种 BMI 轨迹:"低度稳定"(59.2%,n = 946)、"中度"(32.6%,n = 507)和 "高度上升"(8.2%,n = 128)。体重指数变异性的计算方法是将个人体重指数测量值的标准差除以这些测量值的平均值。研究结果显示了线性效应,与低稳定性青少年相比,中等BMI轨迹的参与者的HCC较高(β = 0.10,p = 0.03,95%置信区间(CI) = [0.02-0.40]);然而,在BMI高度上升的青少年中未发现这种关联(β = -0.02,p = 0.71,95% CI = [-0.47-0.32])。在整个发育过程中,较高的体重指数变异性可预测较高的皮质醇(β = 0.17,p = 0.003,95% CI = [0.10-4.91]),与体重指数轨迹的贡献相加。童年时期的 BMI 变异是造成这一结果的原因,这可能表明存在时间效应:这项研究加强了对 BMI 与HCC 关联性的实证支持,并建议除了关注 BMI 的持续轨迹外,还应更加关注 BMI 的波动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Body mass index across development and adolescent hair cortisol: the role of persistence, variability, and timing of exposure.

Background: Research suggests a putative role of the glucocorticoid stress hormone cortisol in the accumulation of adiposity. However, obesity and weight fluctuations may also wear and tear physiological systems promoting adaptation, affecting cortisol secretion. This possibility remains scarcely investigated in longitudinal research. This study tests whether trajectories of body mass index (BMI) across the first 15 years of life are associated with hair cortisol concentration (HCC) measured two years later and whether variability in BMI and timing matter.

Methods: BMI (kg/m2) was prospectively measured at twelve occasions between age 5 months and 15 years. Hair was sampled at age 17 in 565 participants. Sex, family socioeconomic status, and BMI measured concurrently to HCC were considered as control variables.

Results: Latent class analyses identified three BMI trajectories: "low-stable" (59.2%, n = 946), "moderate" (32.6%, n = 507), and "high-rising" (8.2%, n = 128). BMI variability was computed by dividing the standard deviation of an individual's BMI measurements by the mean of these measurements. Findings revealed linear effects, such that higher HCC was noted for participants with moderate BMI trajectories in comparison to low-stable youth (β = 0.10, p = 0.03, 95% confidence interval (CI) = [0.02-0.40]); however, this association was not detected in the high-rising BMI youth (β = -0.02, p = 0.71, 95% CI = [-0.47-0.32]). Higher BMI variability across development predicted higher cortisol (β = 0.17, p = 0.003, 95% CI = [0.10-4.91]), additively to the contribution of BMI trajectories. BMI variability in childhood was responsible for that finding, possibly suggesting a timing effect.

Conclusions: This study strengthens empirical support for BMI-HCC association and suggests that more attention should be devoted to BMI fluctuations in addition to persistent trajectories of BMI.

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来源期刊
International Journal of Obesity
International Journal of Obesity 医学-内分泌学与代谢
CiteScore
10.00
自引率
2.00%
发文量
221
审稿时长
3 months
期刊介绍: The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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