心外膜脂肪组织在心脏重塑中的作用

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-10-02 DOI:10.1016/j.diabres.2024.111878

Rongjun Zou , Miao Zhang , Weihui Lv , Jun Ren , Xiaoping Fan

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引用次数: 0

摘要

心外膜脂肪组织或心外膜脂肪是位于心脏和心包之间的一种内脏脂肪。由于在解剖学上靠近心脏，心外膜脂肪组织在心脏生理和病理（包括心脏重塑和心血管疾病（CVD））中发挥着重要作用。然而，我们对肥胖和 2 型糖尿病等危险因素如何影响 EAT 病理以及 EAT 的改变如何驱动心脏重塑和心血管疾病的了解仍然有限。在此，我们旨在总结和讨论有关 EAT 及其在心脏重塑中作用的最新发现，重点介绍临床和观察性研究的结果，提供机理见解，最后介绍旨在预防这些疾病的新兴治疗药物和营养指南。

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Role of epicardial adipose tissue in cardiac remodeling

Epicardial adipose tissue, or epicardial fat, is a type of visceral fat located between the heart and the pericardium. Due to its anatomical proximity to the heart, EAT plays a significant role in both cardiac physiology and pathologies, including cardiac remodeling and cardiovascular diseases (CVD). However, our understanding of how EAT pathology is influenced by risk factors such as obesity and type 2 diabetes mellitus and how altered EAT can drive cardiac remodeling and CVD, remains limited. Herein, we aimed to summarize and discuss the latest findings on EAT and its role in cardiac remodeling, highlighting the outcomes of clinical and observational studies, provide mechanistic insights, and finally introduce emerging therapeutic agents and nutritional guidelines aimed at preventing these conditions.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.