槐脂:针对微生物生物膜的有效生物分子

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Sunidhi Dhadwal, Shristi Handa, Mary Chatterjee, Ibrahim M Banat
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引用次数: 0

摘要

生物膜是附着在生物或非生物表面的基质中的微生物聚集体,是食品、医疗和海洋行业的严重问题,会对健康和经济产生重大负面影响。生物膜的复杂微生物群落提供了一个难以根除的抗性环境,对抗生素和消毒剂具有极强的抵抗力。对付生物膜有多种传统技术,包括化学清除、物理或机械清除、使用抗生素和消毒剂来消灭产生生物膜的生物。与自由生活的浮游细胞相比,生物膜对这些方法具有很强的抵抗力。因此,迫切需要有别于传统方法的新策略。微生物世界提供了多种有效的 "绿色 "化合物,如生物表面活性剂。它们在生物降解性、优异的稳定性和降低毒性方面优于合成表面活性剂。它们还具有更好的抗粘性和抗生物膜能力,可用于治疗与生物膜有关的问题。槐脂(SL)是一种主要的生物表面活性剂,因其具有抗粘附和抗生物膜的特性而在医疗保健行业引起了极大的兴趣。因此,槐脂可能被证明是一种有吸引力的物质,可在生物医学应用中作为其他抗生素的辅助剂,通过抑制生长和/或破坏生物膜来对抗某些感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sophorolipid: An Effective Biomolecule for Targeting Microbial Biofilms.

Biofilms are microbial aggregates encased in a matrix that is attached to biological or nonbiological surfaces and constitute serious problems in food, medical, and marine industries and can have major negative effects on both health and the economy. Biofilm's complex microbial community provides a resistant environment that is difficult to eradicate and is extremely resilient to antibiotics and sanitizers. There are various conventional techniques for combating biofilms, including, chemical removal, physical or mechanical removal, use of antibiotics and disinfectants to destroy biofilm producing organisms. In contrast to free living planktonic cells, biofilms are very resistant to these methods. Hence, new strategies that differ from traditional approaches are urgently required. Microbial world offers a wide range of effective "green" compounds such as biosurfactants. They outperform synthetic surfactants in terms of biodegradability, superior stabilization, and reduced toxicity concerns. They also have better antiadhesive and anti-biofilm capabilities which can be used to treat biofilm-related problems. Sophorolipids (SLs) are a major type of biosurfactants that have gained immense interest in the healthcare industries because of their antiadhesive and anti-biofilm properties. Sophorolipids may therefore prove to be attractive substances that can be used in biomedical applications as adjuvant to other antibiotics against some infections through growth inhibition and/or biofilm disruption.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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