埃塞俄比亚东阿姆哈拉综合专科医院收治的脑外伤患者的死亡时间及其预测因素：回顾性队列研究。

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2024-10-04 DOI:10.1186/s12883-024-03886-8

Abdurehman Ayele, Samuel Anteneh, Fatuma Seid Degu, Getenet Dessie, Arega Abebe Lonsako, Alemayehu Anley, Gizew Beyene

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引用次数: 0

摘要

背景：据估计，全球每年有 6400-7400 万人遭受脑外伤。中度和严重的创伤性脑损伤可导致终生的身体、认知、情感和行为变化。埃塞俄比亚有关脑外伤死亡率的研究十分有限：方法：研究人员对东阿姆哈拉综合专科医院在 2016 年 1 月 1 日至 2021 年 12 月 31 日期间随机选取的 429 名年龄在 18 至 64 岁之间的创伤性脑损伤患者进行了一项基于机构的回顾性队列研究。Kobo工具箱用于数据收集，并导出到Stata 17版进行数据处理和分析。为估算无死亡时间，采用了卡普兰-梅耶失败曲线。在5%的显著性水平下，使用Cox比例危险回归模型来确定预测变量对死亡时间的影响：共纳入了 429 名年龄在 18 至 64 岁之间的脑外伤患者，应答率为 91.3%，其中 145 人（33.8%）死亡。开放性损伤（AHR = 0.25；95% CI：0.18-0.36）、并存损伤（AHR = 0.40；95% CI：0.24-0.66）、入住重症监护室（AHR = 0.42；95% CI：0.29-0.60）、4-24 小时内到达（AHR = 3.48；95% CI：2.01-6.03）、24 h 后到达（AHR = 6.69；95% CI：3.49-12.28）、硬膜下血肿（AHR = 2.72；95% CI：1.77-4.19）、血清白蛋白结论：研究结果显示，死亡率占患者总数的 1/3。开放性损伤、并存损伤、入住重症监护室、到达时间（4-24 小时和大于 24 小时）、硬膜下血肿、血清白蛋白

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Time to death and its predictors among traumatic brain injury patients admitted to East Amhara comprehensive specialized hospitals, Ethiopia: retrospective cohort study.

Background: Globally, 64-74 million individuals around the world are estimated to sustain traumatic brain injury every year. Moderate and severe traumatic brain injury can lead to a lifetime physical, cognitive, emotional, and behavioral changes. There were limited studies conducted in Ethiopia regarding to traumatic brain injury mortality.

Methods: An institutional based retrospective cohort study was conducted on 429 randomly selected traumatic brain injury patients aged 18 to 64 years who were admitted to East Amhara Comprehensive Specialized Hospitals from January 1, 2016 to December 31, 2021. Kobo toolbox was applied for data collection and exported to Stata version 17 for data processing and analysis. To estimate death free time, a Kaplan Meier failure curve was used. The Cox proportional hazards regression model was used at the 5% level of significance to determine effect of predictor variables on time to death.

Result: A total of 429 traumatic brain injury patients aged 18 to 64 years were included with response rate of 91.3% and 145(33.8%) were dead. Open injuries (AHR = 0.25; 95% CI: 0.18-0.36), co-existing injuries (AHR = 0.40; 95% CI: 0.24-0.66), ICU admission (AHR = 0.42; 95% CI: 0.29-0.60), arrival within 4-24 h (AHR = 3.48; 95% CI: 2.01-6.03), arrival after 24 h (AHR = 6.69; 95% CI: 3.49-12.28), subdural hematoma (AHR = 2.72; 95% CI: 1.77-4.19), serum albumin < 3.5 g/dL (AHR = 0.66; 95% CI: 0.49-0.94), moderate (AHR = 0.56; 95% CI: 0.21-0.89), and mild traumatic brain injury (AHR = 0.43; 95% CI: 0.29-0.56) were predictors of traumatic brain injury mortality.

Conclusion: The finding of this study showed that the mortality was 1/3rd of the total patients. Open injuries, co-existing injuries, ICU admission, arrival time (4-24 h and > 24 h), subdural hematoma, serum albumin < 3.5 g/dL and severity of traumatic brain injury (mild and moderate) were predictors of traumatic brain mortality. Therefore, working on these factors to reduce the morality of traumatic brain injury patients is very important.

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.