lncRNAs调控乳腺癌转移的分子机制;全面综述。

IF 1.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shokoufeh Ahmadi, Farzaneh Yazdi, Sahar Khastar, Irwanjot Kaur, Mareb Hamed Ahmed, Abhishek Kumar, Gulshan Rathore, Parjinder Kaur, Mohammad Shahsavan, Mahmoud Dehghani-Ghorbi, Reza Akhavan-Sigari
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引用次数: 0

摘要

虽然乳腺癌死亡人数有所下降,而且治疗转移性疾病的靶向疗法和综合疗法也有所发展,但转移性乳腺癌仍是美国女性癌症相关死亡的第二大常见原因。入侵-转移级联过程涉及多个阶段、大量蛋白质和信号分子。肿瘤细胞穿透并进入血液或淋巴管,并通过淋巴管或血管到达远处器官。肿瘤细胞进入细胞周期停滞期,粘附在目标器官的毛细血管床上,然后扩散到整个器官的实质组织中,增殖并增强血管生成。这些过程中的每一个都受到不同基因表达变化的调控,其中lncRNA在调控中发挥着作用。长度超过 200 个核苷酸且不能转化为蛋白质的转录本被称为 RNA。LncRNA 分子的功能取决于其独特的分子结构,在控制不同表观遗传水平的基因表达、转录等方面发挥着重要作用。LncRNA 在调节与健康和病理过程中的细胞发育、特化、细胞程序性死亡、细胞分裂、入侵、DNA 损伤以及向身体其他部位扩散有关的基因表达方面具有重要功能。许多癌症类型都显示出 lncRNAs 的异常表达。在这篇综述中,我们描述了lncRNAs的一般特征、潜在分子机制和靶向治疗,并讨论了lncRNAs在乳腺癌中的新功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Mechanism of lncRNAs in Regulation of Breast Cancer Metastasis; a Comprehensive Review.

Although the number of breast cancer deaths has decreased, and there have been developments in targeted therapies and combination treatments for the management of metastatic illness, metastatic breast cancer is still the second most common cause of cancer-related deaths in U.S. women. Numerous phases and a vast number of proteins and signaling molecules are involved in the invasion-metastasis cascade. The tumor cells penetrate and enter the blood or lymphatic vessels, and travel to distant organs via the lymphatic or blood vessels. Tumor cells enter cell cycle arrest, adhere to capillary beds in the target organ, and then disseminate throughout the organ's parenchyma, proliferating and enhancing angiogenesis. Each of these processes is regulated by changes in the expression of different genes, in which lncRNAs play a role in this regulation. Transcripts that are longer than 200 nucleotides and do not translate into proteins are called RNAs. LncRNA molecules, whose function depends on their unique molecular structure, play significant roles in controlling the expression of genes at various epigenetic levels, transcription, and so on. LncRNAs have essential functions in regulating the expression of genes linked to cell development in healthy and pathological processes, specialization, programmed cell death, cell division, invasion, DNA damage, and spread to other parts of the body. A number of cancer types have been shown to exhibit aberrant expression of lncRNAs. In this review, we describe the general characteristics, potential molecular mechanisms and targeted therapy of lncRNAs and discuss the emerging functions of lncRNAs in breast cancer.

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来源期刊
Cell Biochemistry and Biophysics
Cell Biochemistry and Biophysics 生物-生化与分子生物学
CiteScore
4.40
自引率
0.00%
发文量
72
审稿时长
7.5 months
期刊介绍: Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.
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