DNA 甲基化驱动星形胶质细胞的干性

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-10-04 DOI:10.1038/s41593-024-01780-7

George Andrew S. Inglis

引用次数: 0

摘要

脑室-室下区（vSVZ）等脑区的星形胶质细胞是神经干细胞（NSC），尽管它们与非神经源星形胶质细胞有相似的转录组特征。在最近的《自然》杂志研究中，Kremer、Cerrizuela等人利用单细胞核糖体、甲基组和转录组测序，评估转录组或表观基因组程序是否有助于成年小鼠的神经源潜能或星形胶质细胞干性。他们的分析得出了两个转录相似但DNA甲基化模式不同的星形胶质细胞系细胞亚群（qNSC1和qNSC2）：qNSC1细胞与非神经源性纹状体星形胶质细胞共享甲基组，而qNSC2的甲基组与活跃的NSC相似。当作者将成年小鼠暴露于短暂缺血损伤时，vSVZ 星形胶质细胞采用了 NSC 的命运和甲基组。然而，缺乏DNA甲基化新生所需的DNMT3A甲基转移酶的小鼠并没有表现出对缺血损伤的神经源反应。这些结果表明，DNA 甲基化和甲基组重塑在决定星形胶质细胞是否充当 NSCs 方面起着至关重要的作用：自然 https://doi.org/10.1038/s41586-024-07898-9 (2024)

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.