下调不变链会导致自反应 T 细胞扩增

IF 29.4 1区 医学 Q1 RHEUMATOLOGY
Maria Papatriantafyllou
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引用次数: 0

摘要

在缺乏不变链的情况下,由 MHC-II 分子呈现的新自身抗原会驱动系统性红斑狼疮患者自身反应性 T 细胞的克隆扩增。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Downregulation of invariant chain causes autoreactive T cell expansion
Neoself-antigens presented by MHC-II molecules in the absence of invariant chain drive clonal expansion of autoreactive T cells in SLE.
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来源期刊
Nature Reviews Rheumatology
Nature Reviews Rheumatology 医学-风湿病学
CiteScore
29.90
自引率
0.90%
发文量
137
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.
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