肯尼亚妇女凝血指标与月经过多之间的关系。

IF 1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
African Journal of Laboratory Medicine Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI:10.4102/ajlm.v13i1.2438
Phidelis M Marabi, Stanslaus K Musyoki, Fred Monari, Paul M Kosiyo, Collins Ouma
{"title":"肯尼亚妇女凝血指标与月经过多之间的关系。","authors":"Phidelis M Marabi, Stanslaus K Musyoki, Fred Monari, Paul M Kosiyo, Collins Ouma","doi":"10.4102/ajlm.v13i1.2438","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Despite the significant burden of menorrhagia (bleeding > 80 mL every menstrual cycle) among women in Western Kenya, it remains unknown whether coagulation disorders are an important underlying cause of this condition in the region.</p><p><strong>Objective: </strong>This study assessed differences in coagulation profiles, associations between menorrhagia and coagulation profiles and compared morphological features of platelets among women attending Bungoma County Referral Hospital in Kenya.</p><p><strong>Methods: </strong>A comparative cross-sectional study of women with and without menorrhagia, aged 18-45 years, was performed between December 2022 and September 2023. Sociodemographic factors, prothrombin time (PT), activated partial thromboplastin time, thrombin time, fibrinogen, international normalised ratio (INR), and platelet count were compared between groups, and associations with menorrhagia were assessed. Prothrombin time and INR levels above normal references were deemed increased.</p><p><strong>Results: </strong>A total of 428 (214 per group) women were included. Family history of bleeding disorders (<i>p</i> < 0.0001) was more frequent in menorrhagic than in non-menorrhagic women. Additionally, menorrhagic women had high PT (<i>p</i> < 0.0001) and high INR (<i>p</i> < 0.0001) levels. Menorrhagia was significantly associated with an increased PT (odds ratio = 2.129, 95% confidence interval = 1.658-2.734; <i>p</i> < 0.0001) and increased INR (odds ratio = 7.479, 95% confidence interval = 3.094-18.080; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>In this population in Western Kenya, menorrhagia was associated with a family history of bleeding disorders, increased PT, and increased INR. Routine assessment of the coagulation profile and family history of bleeding disorders is crucial for diagnosing and managing menorrhagia.</p><p><strong>What this study adds: </strong>Our findings suggest that menorrhagic and non-menorrhagic women differ in terms of PT and INR, which may be predictive of menorrhagia.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2438"},"PeriodicalIF":1.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447587/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between coagulation indicators and menorrhagia among women in Kenya.\",\"authors\":\"Phidelis M Marabi, Stanslaus K Musyoki, Fred Monari, Paul M Kosiyo, Collins Ouma\",\"doi\":\"10.4102/ajlm.v13i1.2438\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Despite the significant burden of menorrhagia (bleeding > 80 mL every menstrual cycle) among women in Western Kenya, it remains unknown whether coagulation disorders are an important underlying cause of this condition in the region.</p><p><strong>Objective: </strong>This study assessed differences in coagulation profiles, associations between menorrhagia and coagulation profiles and compared morphological features of platelets among women attending Bungoma County Referral Hospital in Kenya.</p><p><strong>Methods: </strong>A comparative cross-sectional study of women with and without menorrhagia, aged 18-45 years, was performed between December 2022 and September 2023. Sociodemographic factors, prothrombin time (PT), activated partial thromboplastin time, thrombin time, fibrinogen, international normalised ratio (INR), and platelet count were compared between groups, and associations with menorrhagia were assessed. Prothrombin time and INR levels above normal references were deemed increased.</p><p><strong>Results: </strong>A total of 428 (214 per group) women were included. Family history of bleeding disorders (<i>p</i> < 0.0001) was more frequent in menorrhagic than in non-menorrhagic women. Additionally, menorrhagic women had high PT (<i>p</i> < 0.0001) and high INR (<i>p</i> < 0.0001) levels. Menorrhagia was significantly associated with an increased PT (odds ratio = 2.129, 95% confidence interval = 1.658-2.734; <i>p</i> < 0.0001) and increased INR (odds ratio = 7.479, 95% confidence interval = 3.094-18.080; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>In this population in Western Kenya, menorrhagia was associated with a family history of bleeding disorders, increased PT, and increased INR. Routine assessment of the coagulation profile and family history of bleeding disorders is crucial for diagnosing and managing menorrhagia.</p><p><strong>What this study adds: </strong>Our findings suggest that menorrhagic and non-menorrhagic women differ in terms of PT and INR, which may be predictive of menorrhagia.</p>\",\"PeriodicalId\":45412,\"journal\":{\"name\":\"African Journal of Laboratory Medicine\",\"volume\":\"13 1\",\"pages\":\"2438\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447587/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/ajlm.v13i1.2438\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/ajlm.v13i1.2438","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

摘要

背景:尽管肯尼亚西部妇女月经过多(每个月经周期出血量大于 80 毫升)的负担沉重,但凝血功能障碍是否是该地区这种情况的重要潜在原因仍不得而知:本研究评估了在肯尼亚邦戈马县转诊医院就诊的妇女在凝血功能方面的差异、月经过多与凝血功能之间的关联,并比较了血小板的形态特征:方法:2022 年 12 月至 2023 年 9 月期间,对患有和未患有月经过多的 18-45 岁女性进行了横断面比较研究。比较了各组之间的社会人口学因素、凝血酶原时间(PT)、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原、国际正常化比率(INR)和血小板计数,并评估了与月经过多的关系。超过正常参考值的凝血酶原时间和 INR 水平被视为增高:共纳入 428 名妇女(每组 214 人)。出血性疾病家族史(p < 0.0001)在月经过多妇女中的发生率高于非月经过多妇女。此外,月经过多妇女的 PT(P < 0.0001)和 INR(P < 0.0001)水平较高。月经过多与 PT 值升高(几率比 = 2.129,95% 置信区间 = 1.658-2.734;p < 0.0001)和 INR 值升高(几率比 = 7.479,95% 置信区间 = 3.094-18.080;p < 0.0001)明显相关:在肯尼亚西部的这一人群中,月经过多与出血性疾病家族史、PT 增高和 INR 增高有关。对凝血功能和出血性疾病家族史进行常规评估对于诊断和治疗月经过多至关重要:我们的研究结果表明,月经过多和非月经过多的女性在 PT 和 INR 方面存在差异,这可能是月经过多的预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between coagulation indicators and menorrhagia among women in Kenya.

Background: Despite the significant burden of menorrhagia (bleeding > 80 mL every menstrual cycle) among women in Western Kenya, it remains unknown whether coagulation disorders are an important underlying cause of this condition in the region.

Objective: This study assessed differences in coagulation profiles, associations between menorrhagia and coagulation profiles and compared morphological features of platelets among women attending Bungoma County Referral Hospital in Kenya.

Methods: A comparative cross-sectional study of women with and without menorrhagia, aged 18-45 years, was performed between December 2022 and September 2023. Sociodemographic factors, prothrombin time (PT), activated partial thromboplastin time, thrombin time, fibrinogen, international normalised ratio (INR), and platelet count were compared between groups, and associations with menorrhagia were assessed. Prothrombin time and INR levels above normal references were deemed increased.

Results: A total of 428 (214 per group) women were included. Family history of bleeding disorders (p < 0.0001) was more frequent in menorrhagic than in non-menorrhagic women. Additionally, menorrhagic women had high PT (p < 0.0001) and high INR (p < 0.0001) levels. Menorrhagia was significantly associated with an increased PT (odds ratio = 2.129, 95% confidence interval = 1.658-2.734; p < 0.0001) and increased INR (odds ratio = 7.479, 95% confidence interval = 3.094-18.080; p < 0.0001).

Conclusion: In this population in Western Kenya, menorrhagia was associated with a family history of bleeding disorders, increased PT, and increased INR. Routine assessment of the coagulation profile and family history of bleeding disorders is crucial for diagnosing and managing menorrhagia.

What this study adds: Our findings suggest that menorrhagic and non-menorrhagic women differ in terms of PT and INR, which may be predictive of menorrhagia.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
African Journal of Laboratory Medicine
African Journal of Laboratory Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.70
自引率
9.10%
发文量
53
审稿时长
12 weeks
期刊介绍: The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信