肿瘤化疗耐药性的分子机制（综述）。

IF 3.8 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2024-11-01 Epub Date: 2024-10-04 DOI:10.3892/or.2024.8816

Xin Weng, Wei-Hong Zeng, Li-Yuan Zhong, Li-Hua Xie, Wen-Jun Ge, Zhen Lai, Qin Qin, Peng Liu, De-Liang Cao, Xi Zeng

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引用次数: 0

摘要

化疗仍然是治疗各种肿瘤的常用方法；然而，大多数接受常规化疗的患者都会出现不同程度的化疗耐药性，最终导致治疗效果不理想。本文深入综述了肿瘤的化疗耐药性，强调了导致肿瘤细胞产生这种耐药性的潜在因素。文章还探讨了在识别主要化疗耐药途径中的关键分子和分子机制方面的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The molecular mechanisms of chemotherapeutic resistance in tumors (Review).

Chemotherapy remains a prevalent treatment for a wide range of tumors; however, the majority of patients undergoing conventional chemotherapy experience varying levels of chemoresistance, ultimately leading to suboptimal outcomes. The present article provided an in‑depth review of chemotherapy resistance in tumors, emphasizing the underlying factors contributing to this resistance in tumor cells. It also explored recent advancements in the identification of key molecules and molecular mechanisms within the primary chemoresistant pathways.

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来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.