帕金森病患者睡眠棘波的改变与认知能力下降之间的关系。

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2024-10-01 DOI:10.1016/j.neulet.2024.138006

Christopher I. Villamar-Flores , Mayela Rodríguez-Violante , Arturo Abundes-Corona , Vanessa Alatriste-Booth , Matilde Valencia-Flores , Yaneth Rodríguez-Agudelo , Amín Cervantes-Arriaga , Rodolfo Solís-Vivanco

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引用次数: 0

摘要

背景：睡眠的宏观和微观结构特征对认知具有相关作用。尽管有报道称包括帕金森病（PD）在内的神经退行性疾病患者的睡眠宏观结构发生了改变，但微观结构（睡眠棘波）的改变与这种疾病的整体认知障碍之间是否存在关系尚不清楚：探讨睡眠的宏观和微观结构（睡眠棘波）与帕金森病患者总体认知状态之间的关系：33名特发性帕金森病患者接受了一晚多导睡眠图（PSG）检查和蒙特利尔认知评估（MoCA）测试的总体认知评估。我们获得了基于 PSG 的宏观睡眠结构值以及睡眠棘波的量化和频谱估计值：结果：我们发现，与健康成人报告的数值相比，总睡眠时间、快速眼动（REM）睡眠潜伏期和 N1 阶段百分比均有所增加，而快速眼动睡眠百分比和睡眠效率则有所下降。与预期值相比，额叶区域的睡眠轴数量有所减少。认知障碍患者的睡眠棘波数量更少，而潜在的西格玛波（12-16 赫兹）（快速棘波）的振幅却有所增加。在探究MoCA子域时，我们发现睡眠棘波的数量和振幅与注意力能力之间存在一致的关系：结论：睡眠棘波的数量减少和振幅增加与帕金森病患者的认知障碍有关，尤其是在注意力能力方面。因此，睡眠棘波的特征可作为认知功能退化的预后指标。

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Association between alterations in sleep spindles and cognitive decline in persons with Parkinson’s disease

Background

Sleep macro and microstructural features have a relevant role for cognition. Although alterations in sleep macrostructure have been reported in persons with neurodegenerative disorders, including Parkinson’s disease (PD), it is unknown whether there is a relationship between alterations in microstructure (sleep spindles) and global cognitive deficits in this disease.

Objective

To explore the association between the macro and microstructure of sleep (sleep spindles) and the general cognitive state in persons with PD.

Methods

Thirty-three patients with idiopathic PD underwent a one-night polysomnography (PSG) and a global cognitive assessment using the Montreal Cognitive Assessment (MoCA) test. PSG-based macrostructural sleep values and quantification and spectral estimation of sleep spindles were obtained.

Results

We found increases in total sleep time, latency to rapid eye movement (REM) sleep, and percentage of N1 stage, as well as a decrease in percentage of REM sleep and sleep efficiency compared to values reported in healthy adults. Compared to expected values, a decrease in the number of sleep spindles was found at frontal regions. Participants with cognitive impairment showed an even lower count of sleep spindles, as well as an increase in the amplitude of underlying sigma (12–16 Hz) waves (fast spindles). When exploring MoCA subdomains, we found a consistent relationship between the number and amplitude of sleep spindles and attention capacity.

Conclusions

Decreased number and increased amplitude of sleep spindles are linked to cognitive impairment in persons with PD, especially in attention capacity. Therefore, sleep spindles characteristics could serve as prognostic indicators of cognitive deterioration in PD.

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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