多变量和网络病变映射揭示了脑卒中后特定领域认知障碍的独特结构。

IF 2 3区心理学 Q3 BEHAVIORAL SCIENCES

Neuropsychologia Pub Date : 2024-10-02 DOI:10.1016/j.neuropsychologia.2024.109007

Margaret Jane Moore , Jason B. Mattingley , Nele Demeyere

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引用次数: 0

摘要

研究背景本研究的目的是确定结构断裂的模式以及多变量病变与行为之间的关系，这些关系与脑卒中后六个常见认知领域的缺陷有关：执行功能、语言、记忆、数字处理、练习和视觉空间注意力：方法：脑卒中幸存者（n = 593）在急性期住院期间完成了一项简短的特定领域认知评估（牛津认知筛查（OCS））。我们进行了网络水平和多变量（sparce canonical correlation）病变映射分析，以确定与 16 项 OCS 测量中的每项损伤相关的病灶神经相关性和分布式结构断裂模式：网络水平和多变量病变映射分析分别确定了 12/16 项和 10/16 项 OCS 测量的显著相关性，这些相关性与过去工作中报告的相关性基本一致。语言障碍与网络和体素水平相关性的可靠定位集中在左侧额颞区。记忆障碍与左半球大区域网络的断开有关。数字处理缺陷与以左侧岛叶/丘脑皮层为中心的体素受损以及周围白质束的断裂有关。在注意力领域，不同亚型的视觉空间忽视与不同但部分重叠的断连模式和体素水平损伤有关。练习障碍与任何体素水平区域均无关联，但与左半球背侧注意力网络的断连有显著关联：这些结果凸显了常规的、特定领域的认知评估和成像数据在理论驱动的病变映射分析中的实用性，同时为卒中后常见的、使人衰弱的认知障碍的复杂解剖相关性提供了新的见解。

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Multivariate and network lesion mapping reveals distinct architectures of domain-specific post-stroke cognitive impairments

Background

The purpose of this study was to identify patterns of structural disconnection and multivariate lesion-behaviour relationships associated with post-stroke deficits across six commonly impacted cognitive domains: executive function, language, memory, numerical processing, praxis, and visuospatial attention.

Methods

Stroke survivors (n = 593) completed a brief domain-specific cognitive assessment (the Oxford Cognitive Screen (OCS)) during acute hospitalisation. Network-level and multivariate (sparce canonical correlation) lesion mapping analyses were conducted to identify focal neural correlates and distributed patterns of structural disconnection associated with impairment on each of the 16 OCS measures.

Results

Network-level and multivariate lesion mapping analyses identified significant correlates for 12/16 and 10/16 OCS measures, respectively which were largely consistent with correlates reported in past work. Language impairments were reliably localised to network- and voxel-level correlates centred in left fronto-temporal regions. Memory impairments were associated with disconnection in a large network of left hemisphere regions. Number processing deficits were associated with damage to voxels centred in the left insular/opercular cortex, as well as disconnection within the surrounding white matter tracts. Within the domain of attention, different subtypes of visuospatial neglect were linked to distinct but partially overlapping patterns of disconnection and voxel-level damage. Praxis impairment was not linked to any voxel-level regions but was significantly associated with disconnection within the left hemisphere dorsal attention network.

Conclusion

These results highlight the utility of routine, domain-specific cognitive assessment and imaging data for theoretically-driven lesion mapping analyses, while providing novel insight into the complex anatomical correlates of common and debilitating post-stroke cognitive impairments.

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来源期刊

Neuropsychologia 医学-行为科学

CiteScore

5.10

自引率

3.80%

发文量

228

审稿时长

4 months

期刊介绍： Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.