在动物实验中应用盲法和随机化的方法。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
P S Verhave, R van Eenige, Iacw Tiebosch
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引用次数: 0

摘要

盲法和随机化是提高临床前研究稳健性的重要方法,因为盲法和随机化的不完全或不当实施被认为是偏差的来源。随机化可确保任何会产生偏差的已知和未知协变量在实验组中随机分布。这样,实验组之间的差异就会减少,否则可能会造成假阳性或假阴性结果。随机化的方法多种多样,从简单的随机化(如掷骰子)到使用专门软件的高级随机化策略,不一而足。另一方面,盲法可确保研究人员在准备、执行、获取和/或分析数据期间不知道组别分配情况。这就最大限度地降低了无意影响导致偏差的风险。盲法需要强有力的协议和团队合作。在这篇综述中,我们概述了随机化和盲法的方法,并以动物研究为重点,提供了如何实施这些方法的实用技巧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Methods for applying blinding and randomisation in animal experiments.

Blinding and randomisation are important methods for increasing the robustness of pre-clinical studies, as incomplete or improper implementation thereof is recognised as a source of bias. Randomisation ensures that any known and unknown covariates introducing bias are randomly distributed over the experimental groups. Thereby, differences between the experimental groups that might otherwise have contributed to false positive or -negative results are diminished. Methods for randomisation range from simple randomisation (e.g. rolling a dice) to advanced randomisation strategies involving the use of specialised software. Blinding on the other hand ensures that researchers are unaware of group allocation during the preparation, execution and acquisition and/or the analysis of the data. This minimises the risk of unintentional influences resulting in bias. Methods for blinding require strong protocols and a team approach. In this review, we outline methods for randomisation and blinding and give practical tips on how to implement them, with a focus on animal studies.

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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
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