{"title":"在脱漆工作中接触苯甲醇的工人尿液中的苯甲醇和喜树酸。","authors":"Kenta Ishii, Akito Takeuchi, Masami Shimada, Hiromi Momokawa, Tomiko Tashiro, Ai Yamada, Kumiko Arai, Akira Namera, Kenji Yamamuro, Koichi Kato, Toshihiro Kawamoto, Ginji Endo","doi":"10.1093/joccuh/uiae059","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>We aimed to develop a reliable gas chromatography-mass spectrometry (GC-MS) method for detecting urinary benzyl alcohol (BeOH) concentrations and assess the suitability of urinary BeOH as a biomarker for occupational BeOH exposure.</p><p><strong>Methods: </strong>Thirteen male participants exposed to BeOH during paint-stripping work provided preshift and postshift urine samples, and their personal exposure concentrations were measured. Meanwhile, a control group of 10 nonexposed workers contributed urine samples. The newly developed GC-MS method met regulatory guidelines.</p><p><strong>Results: </strong>The personal exposure concentrations of BeOH ranged from 8.4 to 45.2 mg/m3. Postshift urine samples from exposed participants showed significant BeOH and hippuric acid (HA) concentration increases compared with preshift samples (BeOH, post-/pre-shift geometric mean [GM] ratio = 7.5-7.8, P < .001; HA, post-/pre-shift GM ratio = 4.3-4.5, P < .001). These levels were considerably higher than those in postshift samples from the nonexposed control group (BeOH, exposed-/nonexposed-workers GM ratio = 14.8-19.0, P < .001; HA, exposed-/nonexposed-workers GM ratio = 12.1-15.3, P < .001), even after urine density correction.</p><p><strong>Conclusions: </strong>Urinary BeOH and HA can serve as potential biomarkers of occupational exposure to BeOH. More specifically, BeOH might serve as a biomarker superior to HA because it is apparently less influenced by confounding factors such as dietary intake and genetic polymorphism of low-Km aldehyde dehydrogenase (ALDH2). The findings will improve workplace safety measures and protocols, assisting health care professionals in diagnosing and managing exposure-related health issues, thereby potentially reducing the risk of occupational exposure to BeOH.</p>","PeriodicalId":16632,"journal":{"name":"Journal of Occupational Health","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561903/pdf/","citationCount":"0","resultStr":"{\"title\":\"Urinary benzyl alcohol and hippuric acid in workers exposed to benzyl alcohol during paint-stripping work.\",\"authors\":\"Kenta Ishii, Akito Takeuchi, Masami Shimada, Hiromi Momokawa, Tomiko Tashiro, Ai Yamada, Kumiko Arai, Akira Namera, Kenji Yamamuro, Koichi Kato, Toshihiro Kawamoto, Ginji Endo\",\"doi\":\"10.1093/joccuh/uiae059\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>We aimed to develop a reliable gas chromatography-mass spectrometry (GC-MS) method for detecting urinary benzyl alcohol (BeOH) concentrations and assess the suitability of urinary BeOH as a biomarker for occupational BeOH exposure.</p><p><strong>Methods: </strong>Thirteen male participants exposed to BeOH during paint-stripping work provided preshift and postshift urine samples, and their personal exposure concentrations were measured. Meanwhile, a control group of 10 nonexposed workers contributed urine samples. The newly developed GC-MS method met regulatory guidelines.</p><p><strong>Results: </strong>The personal exposure concentrations of BeOH ranged from 8.4 to 45.2 mg/m3. Postshift urine samples from exposed participants showed significant BeOH and hippuric acid (HA) concentration increases compared with preshift samples (BeOH, post-/pre-shift geometric mean [GM] ratio = 7.5-7.8, P < .001; HA, post-/pre-shift GM ratio = 4.3-4.5, P < .001). These levels were considerably higher than those in postshift samples from the nonexposed control group (BeOH, exposed-/nonexposed-workers GM ratio = 14.8-19.0, P < .001; HA, exposed-/nonexposed-workers GM ratio = 12.1-15.3, P < .001), even after urine density correction.</p><p><strong>Conclusions: </strong>Urinary BeOH and HA can serve as potential biomarkers of occupational exposure to BeOH. More specifically, BeOH might serve as a biomarker superior to HA because it is apparently less influenced by confounding factors such as dietary intake and genetic polymorphism of low-Km aldehyde dehydrogenase (ALDH2). The findings will improve workplace safety measures and protocols, assisting health care professionals in diagnosing and managing exposure-related health issues, thereby potentially reducing the risk of occupational exposure to BeOH.</p>\",\"PeriodicalId\":16632,\"journal\":{\"name\":\"Journal of Occupational Health\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-01-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561903/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Occupational Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/joccuh/uiae059\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Occupational Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/joccuh/uiae059","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Urinary benzyl alcohol and hippuric acid in workers exposed to benzyl alcohol during paint-stripping work.
Objective: We aimed to develop a reliable gas chromatography-mass spectrometry (GC-MS) method for detecting urinary benzyl alcohol (BeOH) concentrations and assess the suitability of urinary BeOH as a biomarker for occupational BeOH exposure.
Methods: Thirteen male participants exposed to BeOH during paint-stripping work provided preshift and postshift urine samples, and their personal exposure concentrations were measured. Meanwhile, a control group of 10 nonexposed workers contributed urine samples. The newly developed GC-MS method met regulatory guidelines.
Results: The personal exposure concentrations of BeOH ranged from 8.4 to 45.2 mg/m3. Postshift urine samples from exposed participants showed significant BeOH and hippuric acid (HA) concentration increases compared with preshift samples (BeOH, post-/pre-shift geometric mean [GM] ratio = 7.5-7.8, P < .001; HA, post-/pre-shift GM ratio = 4.3-4.5, P < .001). These levels were considerably higher than those in postshift samples from the nonexposed control group (BeOH, exposed-/nonexposed-workers GM ratio = 14.8-19.0, P < .001; HA, exposed-/nonexposed-workers GM ratio = 12.1-15.3, P < .001), even after urine density correction.
Conclusions: Urinary BeOH and HA can serve as potential biomarkers of occupational exposure to BeOH. More specifically, BeOH might serve as a biomarker superior to HA because it is apparently less influenced by confounding factors such as dietary intake and genetic polymorphism of low-Km aldehyde dehydrogenase (ALDH2). The findings will improve workplace safety measures and protocols, assisting health care professionals in diagnosing and managing exposure-related health issues, thereby potentially reducing the risk of occupational exposure to BeOH.
期刊介绍：
The scope of the journal is broad, covering toxicology, ergonomics, psychosocial factors and other relevant health issues of workers, with special emphasis on the current developments in occupational health. The JOH also accepts various methodologies that are relevant to investigation of occupational health risk factors and exposures, such as large-scale epidemiological studies, human studies employing biological techniques and fundamental experiments on animals, and also welcomes submissions concerning occupational health practices and related issues.
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