中国 COVID-19 患者的 KIR 和 HLA 多态性分析

IF 5.9 4区医学 Q2 CELL BIOLOGY

HLA Pub Date : 2024-10-01 DOI:10.1111/tan.15715

Sudan Tao, Xuan You, Paul J Norman, Katherine M Kichula, Lina Dong, Nanying Chen, Ji He, Wei Zhang, Faming Zhu

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引用次数: 0

摘要

杀伤细胞免疫球蛋白样受体（KIR）与 HLA I 类的相互作用在调节 NK 细胞功能以应对病毒感染方面起着至关重要的作用。为了探索 KIR/HLA 与 SARS-CoV-2 感染易感性之间的相关性，我们分析了 COVID-19 诊断个体中 KIR 基因的多态性、单倍型、HLA 异型以及 KIR 和 HLA 之间的相互作用。与人群对照组相比，我们观察到 COVID-19 组中 KIR3DL3*00802 的频率明显增加。由 HLA-B 基因编码的 HLA-Bw4（KIR3DL1 的配体）在 COVID-19 组中的频率较低。此外，在多重检验校正前，COVID-19 组中 KIR-Bx3、KIR3DL3*00301、3DL3*048 和 C1+HLA-C 的频率明显升高，这表明它们与 SARS-CoV-2 感染的易感性有关。我们的研究结果表明，KIR3DL3*00802等位基因可能是感染SARS-CoV-2的高危因素，而HLA-B基因编码的Bw4可能对感染具有保护作用。

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Analysis of KIR and HLA Polymorphism in Chinese Individuals With COVID-19.

Killer-cell immunoglobulin-like receptor (KIR) interactions with HLA class I have crucial roles in modulating NK cell function in response to viral infections. To explore the correlation between KIR/HLA and susceptibility to SARS-CoV-2 infection, we analysed polymorphism of KIR genes, haplotypes, HLA allotypes, and the interplay between KIR and HLA in individuals diagnosed with COVID-19. Compared to a population control group, we observed a significantly increased frequency of KIR3DL3*00802 in the COVID-19 group. When encoded by the HLA-B gene, the frequency of HLA-Bw4, a ligand for KIR3DL1, was at lower frequency in the COVID-19 group. Additionally, significantly elevated frequencies of KIR-Bx3, KIR3DL3*00301, 3DL3*048, and C1⁺HLA-C were identified in the COVID-19 group before multiple test correction, suggesting associations with susceptibility to SARS-CoV-2 infection. Our findings indicate that the KIR3DL3*00802 allele may be a high-risk factor for SARS-CoV-2 infection, while Bw4 encoded by HLA-B gene may confer protective effects against the infection.

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来源期刊

HLA Immunology and Microbiology-Immunology

CiteScore

3.00

自引率

28.80%

发文量

368

期刊介绍： HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.