世界真奇妙

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2024-10-16 DOI:10.1101/gad.352278.124

Claire Magnon

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引用次数: 0

摘要

癌症科学界正朝着与神经科学建立联系的模式转变。经过数十年对基因不稳定性和突变或肿瘤微环境的研究，新出现的证据表明，恶性肿瘤能够劫持和利用大脑及其外周和中枢神经元网络，破坏体内平衡。全身平衡需要脑-体回路通过相互感知、免疫感知和痛觉过程来维持生存和健康。现在看来，癌症很可能是通过脑肿瘤的双向联系干扰了大脑与身体的生理交流。

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What a wonderful world!

The world of cancer science is moving toward a paradigm shift in making connections with neuroscience. After decades of research on genetic instability and mutations or on the tumor microenvironment, emerging evidence suggests that a malignant tumor is able to hijack and use the brain and its network of peripheral and central neurons as disrupters of homeostasis in the body. Whole-body homeostasis requires brain-body circuits to maintain survival and health via the processes of interoception, immunoception, and nociception. It is now likely that cancer disturbs physiological brain-body communication in making bidirectional brain tumor connections.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).