返老还童因子 PF4：神经退行性疾病的潜在守门人。

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1482922

Fengju Jia, Xiaoli Shen

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引用次数: 0

摘要

最近，人们发现 PF4 是一种认知增强剂，它能提高年轻小鼠的认知能力，并让老年动物恢复中年时的敏锐度。PF4 通过减少衰老过程中的炎症而发挥作用。众所周知，衰老无疑是神经退行性疾病的主要风险因素。此外，炎症已被广泛研究，并引起了更大的兴趣。因此，该提案旨在强调 PF4 在神经退行性疾病炎症过程中的价值，这可能会提供一种潜在的治疗策略。

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Rejuvenation factor PF4: a potential gatekeeper for neurodegenerative diseases.

Recently, it is discovered PF4 is a cognitive enhancer that improved the cognitive abilities of younger mice and gave older animals their middle-aged acuity back. PF4 works by reducing inflammation during the aging process. As we all known, aging is undoubtedly the main risk factor of neurodegenerative diseases. Furthermore, inflammation has been extensively investigated and attracted even more interest. Therefore, the aim of the proposal is to highlight the worth of PF4 in inflammaging of neurodegenerative diseases, which might provide a potential therapeutic strategy.

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.