68Ga-DOTA-FAPI-46 PET/CT 成像用于转移性嗜铬细胞瘤患者的再分期：与 68Ga-DOTA-TATE PET/CT 的比较。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI:10.1097/RLU.0000000000005481

Rahime Şahin, Mehmet Can Baloğlu, Nurhan Ergül, Tevfik Fikret Çermik, Esra Arslan

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引用次数: 0

摘要

摘要：嗜铬细胞瘤（PHEOs）是源于肾上腺髓质嗜铬细胞的神经嵴肿瘤，2022年被世界卫生组织认定为副神经节瘤的亚型之一。68Ga 标记的体生长抑素类似物（68Ga-DOTA-NOC、68Ga-DOTA-TOC 和 68Ga-DOTA-TATE）PET 成像与 123MIBG 闪烁显像相比，在副神经节瘤的诊断中具有显著的疗效。现在已经知道，成纤维细胞活化蛋白（FAP）在各种癌症相关成纤维细胞（包括 PHEOs）中过度表达。我们想介绍对一名被诊断为转移性 PHEO 的 42 岁男性进行 68Ga-DOTA-FAPI-46 PET/CT 和 68Ga-DOTA-TATE PET/CT 重新分期的结果。

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68 Ga-DOTA-FAPI-46 PET/CT Imaging for Restaging in a Patient With Metastatic Pheochromocytoma : Comparison With 68 Ga-DOTA-TATE PET/CT.

Abstract: Pheochromocytomas (PHEOs) are neural crest-derived tumors originating from the chromaffin cells of the adrenal medulla and were recognized as one of the subtypes of paragangliomas by the World Health Organization in 2022. 68 Ga-labeled somatostatin analog ( 68 Ga-DOTA-NOC, 68 Ga-DOTA-TOC, and 68 Ga-DOTA-TATE) PET imaging has shown significant performance compared with 123 MIBG scintigraphy in the diagnosis of paragangliomas. It is now known that fibroblast activation protein (FAP) is overexpressed by various cancer-associated fibroblasts, including PHEOs. We would like to present the findings of 68 Ga-DOTA-FAPI-46 PET/CT and 68 Ga-DOTA-TATE PET/CT imaging performed for restaging on a 42-year-old man diagnosed with metastatic PHEO.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.