用 68Ga-Trivehexin PET/CT 评估卵巢癌中的 "癌症整合素 "αvβ6 成像。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2024-11-01 Epub Date: 2024-10-03 DOI:10.1097/RLU.0000000000005485

Parneet Singh, Kanhaiyalal Agrawal, Ralph Emerson, Abhinav Baranwal, P Sai Sradha Patro, Girish Kumar Parida

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引用次数: 0

摘要

摘要：腹膜癌指数是腹膜疾病术前评估不可或缺的参数。包括 18F-FDG PET/CT 在内的现有成像模式虽然优于 CT，但却低估了疾病的程度，这主要是由于其生理背景活性较高。使用 68Ga-trivehexin 进行的新型 "癌症整合素 "靶向成像显示出腹腔内有限的生理活性，其靶向-背景比优于 18F-FDG PET/CT。因此，我们描述了首例证明新型 "癌症整合素 "αvβ6成像剂68Ga-trivehexin在评估晚期上皮性卵巢癌疾病负担方面潜在用途的病例。

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"Cancer Integrin" α v β 6 Imaging With 68 Ga-Trivehexin PET/CT in Assessment of Ovarian Carcinoma.

Abstract: Peritoneal cancer index is an integral parameter for preoperative assessment of peritoneal disease. Current imaging modalities including 18 F-FDG PET/CT, though superior to CT, underestimate the disease extent, mainly due to its high physiological background activity. Novel "cancer integrin" targeting imaging with 68 Ga-trivehexin demonstrates limited physiological activity in the abdomen with superior target-to-background ratio than 18 F-FDG PET/CT. Thus, we describe the first case demonstrating potential utility of novel "cancer integrin" αvβ6 imaging agent 68 Ga-trivehexin for assessment of disease burden in advanced epithelial ovarian cancer.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.