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引用次数: 0
摘要
细胞信号的保真度需要蛋白质与蛋白质之间相互作用的特异性以及信号分子在亚细胞内的精确定位。就蛋白质磷酸化而言,许多激酶和磷酸酶表现出杂乱的底物配对,因此需要靶向相互作用来修饰适当的底物,避免不同途径之间的交叉干扰。在过去 10 年中,研究人员发现并研究了蛋白激酶 A 催化亚基(PKAc)特定相互作用和亚细胞靶向的缺失是如何导致皮质醇腺瘤和使人衰弱的应激障碍性肾上腺库欣综合征的。本文回顾了有关PKA在产生糖皮质激素的肾上腺细胞中定位的经典研究,并综述了PKA定位紊乱和选择性调控相互作用在肾上腺病理学中的最新证据。
Disruptions to protein kinase A localization in adrenal pathology.
Cell signaling fidelity requires specificity in protein-protein interactions and precise subcellular localization of signaling molecules. In the case of protein phosphorylation, many kinases and phosphatases exhibit promiscuous substrate pairing and therefore require targeting interactions to modify the appropriate substrates and avoid cross-talk among different pathways. In the past 10 years, researchers have discovered and investigated how loss of specific interactions and subcellular targeting for the protein kinase A catalytic subunit (PKAc) lead to cortisol-producing adenomas and the debilitating stress disorder adrenal Cushing's syndrome. This article reviews classical studies regarding PKA localization in glucocorticoid-producing adrenal cells and synthesizes recent evidence of disrupted PKA localization and selective regulatory interactions in adrenal pathology.
期刊介绍:
Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences.
Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.