四叶草果实酚类成分可防止缺血性中风引起的 Wistar 大鼠海马变形和记忆缺陷。

IF 1.4 Q3 ANATOMY & MORPHOLOGY
Onyinoyi Bethel Onimisi, Sunday Abraham Musa, Uduak Emmanuel Umana, Sonhap James Sambo, Wusa Makena
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引用次数: 0

摘要

中风是导致全球残疾的最主要原因。尽管有越来越多的数据支持中风后的记忆缺失,但功能障碍和治疗效果机制仍然未知。各种水果和蔬菜中都含有酚类物质。然而,有关四叶草(PTT)果实中的酚类成分对缺血性中风引起的海马组织异常的治疗潜力的研究却很少。将大鼠分为五组:第一组,车辆;第二组,缺血再灌注(I/R)+车辆;第三组,I/R+50 mg/kg 米诺环素(MNC);第四组,I/R+100 mg/kg PTT;第五组,I/R+200 mg/kg PTT。通过双侧颈总动脉闭塞诱导缺血 30 分钟,然后再灌注。每天口服 PTT 和 MNC,连续 7 天。对大鼠的神经退行性变化、1号角锥体(CA1)和3号角锥体(CA3)锥体细胞数量、氧化应激指标水平和记忆功能进行评估。与未接受 I/R 治疗的大鼠相比,接受 PTT 和 MNC 治疗的大鼠的记忆功能大幅提高(PPP
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tetrapleura tetraptera fruit phenolics fraction protects against the impact of ischemic stroke-induced hippocampal distortions and memory deficits in Wistar rats.

Stroke is the most significant cause of disability worldwide. Despite mounting data supporting memory deficit after stroke, dysfunction and treatment effect mechanisms remain unknown. Phenolics can be found in a variety of fruits and vegetables. There is, however, a scarcity of research on the therapeutic potential of the phenolics fraction of Tetrapleura tetraptera (PTT) fruit against ischemic stroke-induced abnormalities in hippocampal tissue. The rats were divided into five groups: Group I, vehicle; group II, ischemia/reperfusion (I/R)+vehicle; group III, I/R+50 mg/kg minocycline (MNC); group IV, I/R+100 mg/kg PTT; and group V, I/R+200 mg/kg PTT. Ischemia was induced via bilateral common carotid artery occlusion for 30 minutes followed by reperfusion. PTT and MNC were intraorally administered daily for 7 days. Neurodegenerative changes, cornu ammonis 1 (CA1) and cornu ammonis 3 (CA3) pyramidal cell count, levels of oxidative stress indicators, and memory functions were assessed. Rats treated with PTT, as well as MNC compared to untreated I/R rats, showed a substantial (P<0.05) rise in catalase, superoxide dismutase, glutathione levels, as well as decreased lipid peroxidation and improved memory. I/R resulted in histoarchitectural distortions, a marked decrease (P<0.05) in the intensity of the Nissl substance, and a striking decrease (P<0.05) in the number of pyramidal cells in the CA1 and CA3. PTT and MNC-treated groups showed significant attenuation in all the above parameters. Taking together, these findings revealed that PTT attenuated oxidative stress, histologic alterations and substantially restored memory impairment in the I/R rat model.

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来源期刊
Anatomy & Cell Biology
Anatomy & Cell Biology ANATOMY & MORPHOLOGY-
CiteScore
1.80
自引率
9.10%
发文量
75
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