Ke Zhao, Tingting Si, Shenghe Liu, Gaolei Liu, Donghao Li, Fengxiang Li
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Co-metabolism of microorganisms: A study revealing the mechanism of antibiotic removal, progress of biodegradation transformation pathways.
The widespread use of antibiotics has resulted in large quantities of antibiotic residues entering aquatic environments, which can lead to the development of antibiotic-resistant bacteria and antibiotic-resistant genes, posing a potential environmental risk and jeopardizing human health. Constructing a microbial co-metabolism system has become an effective measure to improve the removal efficiency of antibiotics by microorganisms. This paper reviews the four main mechanisms involved in microbial removal of antibiotics: bioaccumulation, biosorption, biodegradation and co-metabolism. The promotion of extracellular polymeric substances for biosorption and extracellular degradation and the regulation mechanism of enzymes in biodegradation by microorganisms processes are detailed therein. Transformation pathways for microbial removal of antibiotics are discussed. Bacteria, microalgae, and microbial consortia's roles in antibiotic removal are outlined. The factors influencing the removal of antibiotics by microbial co-metabolism are also discussed. Overall, this review summarizes the current understanding of microbial co-metabolism for antibiotic removal and outlines future research directions.
期刊介绍:
The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere.
The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.