B-133 尿酸：描述 2022 年期间在一家综合医院接受治疗的成年患者的尿酸值

IF 7.1 2区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Clinical chemistry Pub Date : 2024-10-02 DOI:10.1093/clinchem/hvae106.494

A I Corominas, G Casal, F Vommaro, S Balconi, A Damiano

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引用次数: 0

摘要

背景尿酸与肾脏疾病、葡萄糖不耐受、高血压、代谢综合征和心血管疾病之间的关系已得到公认。临床实验室有义务为这一指标制定有效的参考区间（RI）。每个特定人群都有自己的遗传基因和饮食习惯，在很多情况下无法进行推断。使用直接方法建立参考区间既困难又昂贵，这促使我们使用电子档案中的现有数据进行回顾性分析。目标：描述 2022 年期间在波萨达斯医院接受治疗的成人门诊患者的尿酸值范围。评估性别和年龄范围对观察值的影响。方法采用回顾性观察法，从罗氏 Infinity 系统数据库实验室信息学（SIL）中获取 2022 年的数据。处理了在该服务机构接受治疗的所有成人门诊患者的相应数据。分析系统：罗氏 Cobas 6000，尿酸酶-氧化酶法。排除标准：肿瘤患者、肾病患者、糖尿病患者、高血糖患者、产科病人、激素病人、在病房治疗的病人和转诊病人。用 Tukey 法排除异常值。统计处理采用 SPSS 17.0 程序。结果我们处理了 91922 组数据。因此，尿酸为 12331。符合排除标准后3899人，其中2289人（3.96 ± 1.05 mg/dl）为50岁女性，747人（4.36 ± 1.15 mg/dl）≥50岁，863人（5.59 ± 1.33 mg/dl）为男性，所有数据均呈正态分布。通过方差分析和学生检验，可以证实除了上述性别间的显著差异外，两个年龄组的女性之间也存在差异（p<0.01），在年龄≥50 岁的女性中，该差异不等于男性的差异。结论有必要进行更广泛的研究，以确定自己的参考范围，从而制定早期预警指南，尤其是在 50 岁女性群体中。这样才能充分评估患者的风险和病情变化。间接法的应用将有可能排除未在 SIL 中登记的潜在病症所对应的数值。

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B-133 Uric acid: A description of the values found in adult patients treated during 2022 in a High Complexity Hospital

Background An association between uric acid and kidney disease, glucose intolerance, high blood pressure, metabolic syndrome and cardiovascular disease has been recognized. It is the obligation of the Clinical Laboratory to have valid reference intervals (RI) for this marker. Each particular population has genetics and a diet that represents it, which cannot be extrapolated in many cases. The difficulty and high cost of using direct methods for its establishment drive us to use the existing data in our electronic archive retrospectively. Objective: to describe the range of uric acid values in adult outpatients treated at the Posadas Hospital during the year 2022. Evaluate the influence of gender and age range on the observed values. Methods A retrospective observational approach was carried out from the System database Laboratory Informatics (SIL), Roche Infinity, from the year 2022. The data corresponding to all adult outpatient patients treated in the service were processed. Analytical System: Roche Cobas 6000, Uricase-Oxidase method. Exclusion criteria: oncology patients, kidney patients, diabetics, hyperglycemic patients, obstetric patients, hormonal patients, treated in wards and referred patients. Outliers excluded by Tukey method. The statistical treatment was carried out with the SPSS 17.0 program. Results We worked with 91922 data groups. Hence 12331 of uric acid. After meeting the exclusion criteria: 3899, of which 2289 (3.96 ± 1.05 mg/dl) correspond to women < 50 years , 747 (4.36 ± 1.15 mg/dl at ≥ 50 years and 863 (5.59 ± 1.33 mg/dl) men, all with normal distributions. Applying ANOVA and Student's test it was possible to verify in addition to the described significant difference between sexes, a difference between the 2 age groups of women (p<0.01) which is not equal to that of men in women ≥ 50 years of age. Conclusions A more extensive study is necessary to define own reference ranges that enable the early alarm guidelines, especially in the group of women < 50 years of age. This will allow an adequate evaluation of risk and evolution of patients. The application of Indirect Methods will make it possible to exclude values corresponding to underlying pathologies not registered in the SIL.

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来源期刊

Clinical chemistry 医学-医学实验技术

CiteScore

11.30

自引率

4.30%

发文量

212

审稿时长

1.7 months

期刊介绍： Clinical Chemistry is a peer-reviewed scientific journal that is the premier publication for the science and practice of clinical laboratory medicine. It was established in 1955 and is associated with the Association for Diagnostics & Laboratory Medicine (ADLM). The journal focuses on laboratory diagnosis and management of patients, and has expanded to include other clinical laboratory disciplines such as genomics, hematology, microbiology, and toxicology. It also publishes articles relevant to clinical specialties including cardiology, endocrinology, gastroenterology, genetics, immunology, infectious diseases, maternal-fetal medicine, neurology, nutrition, oncology, and pediatrics. In addition to original research, editorials, and reviews, Clinical Chemistry features recurring sections such as clinical case studies, perspectives, podcasts, and Q&A articles. It has the highest impact factor among journals of clinical chemistry, laboratory medicine, pathology, analytical chemistry, transfusion medicine, and clinical microbiology. The journal is indexed in databases such as MEDLINE and Web of Science.