生殖中心的免疫代谢调节及其对衰老的影响。

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-10-01 DOI:10.1016/j.coi.2024.102485

Daehong Kim , Jaemin Kim , Hyeonuk Yeo , Yeonseok Chung

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引用次数: 0

摘要

长期以来，衰老、新陈代谢和免疫一直被认为是不同的领域。衰老主要与生理机能的逐渐衰退有关，新陈代谢调节能量的产生并维持细胞过程，而免疫系统则管理针对病原体和疫苗的先天性和适应性反应。然而，最近的研究发现，这三个系统错综复杂地相互关联，共同影响着个体对压力和疾病的反应。本综述探讨免疫代谢、T 滤泡辅助细胞、B 细胞和衰老之间的相互作用，重点是这些相互作用如何影响老年人的免疫功能。

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Immunometabolic regulation of germinal centers and its implications for aging

Aging, metabolism, and immunity have long been considered distinct domains. Aging is primarily associated with the gradual decline of physiological functions, metabolism regulates energy production and maintains cellular processes, and the immune system manages innate and adaptive responses against pathogens and vaccines. However, recent studies have revealed that these three systems are intricately interconnected, collectively influencing an individual’s response to stress and disease. This review explores the interplay between immunometabolism, T follicular helper cells, B cells, and aging, focusing on how these interactions impact immune function in the elderly.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.