COVID-19致死并不影响晚期癌症患者接受姑息治疗的时间:一项回顾性队列研究。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Einstein-Sao Paulo Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.31744/einstein_journal/2024AO0536
Rafael Tavares Jomar, Jéssica Thaís Nascimento Marques, Livia Costa de Oliveira, Gelcio Luiz Quintella Mendes, Daianny Arrais de Oliveira da Cunha, Raphael Mendonça Guimarães
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引用次数: 0

摘要

背景Jomar等人的研究表明,COVID-19导致的死亡不会影响晚期癌症患者接受独家姑息治疗的时间,即使是在这种迄今鲜为人知的疾病引起大流行的第一年。背景:◼COVID-19导致的死亡并不会改变接受肿瘤姑息治疗的时间。背景:◼这一开创性研究的回顾性设计允许进行因果推论:本研究旨在调查COVID-19导致的死亡在多大程度上影响晚期癌症患者接受姑息治疗的时间:在巴西里约热内卢的巴西国立癌症研究所姑息治疗室开展了一项回顾性队列研究,研究对象为2020年3月11日至2021年3月31日期间在独家姑息治疗下死亡的1104名晚期癌症患者。采用Wilcoxon秩和检验(Mann-Whitney U)和log-rank检验来检验时间中位数之间的统计差异,并使用Kaplan-Meier估计器以图表说明两个实验组(癌症组和COVID-19组)在接受独家姑息治疗后随时间推移的存活率,这取决于死亡的基本原因:共有 133 名(12.05%)患者死于 COVID-19。两组患者接受姑息治疗的中位时间均少于一个月。两组患者的姑息治疗生存曲线在统计学上没有明显差异:结论:COVID-19导致的死亡不会改变晚期癌症患者接受姑息治疗的时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fatality from COVID-19 does not affect palliative care duration among patients with advanced cancer: a retrospective cohort study.

Background: Jomar et al. demonstrated that death due to COVID-19 did not affect the time under exclusive palliative care among patients with advanced cancer, even during the first year of the pandemic caused by a hitherto little-known disease.

Background: ◼ Fatality due to COVID-19 does not alter the time under oncological palliative care.

Background: ◼ The retrospective design of this pioneering study allows causal inference.

Background: ◼ Access to oncological palliative care frequently approaches terminality of life.

Objective: This study aimed at investigating the extent to which COVID-19-induced fatalities affect the duration of palliative care among patients with advanced cancer.

Methods: A retrospective cohort study was conducted at the Palliative Care Unit of the Brazilian Instituto Nacional de Câncer in Rio de Janeiro, Brazil, on 1,104 advanced cancer patients who died under exclusive palliative care between March 11, 2020, and March 31, 2021. Wilcoxon rank-sum (Mann-Whitney U) and log-rank tests were performed to examine statistical differences between the medians of time, and the Kaplan-Meier estimator was used to graphically illustrate survival over time under exclusive palliative care contingent upon the underlying causes of death of the two experimental groups (cancer versus COVID-19).

Results: A total of 133 (12.05%) patients succumbed to COVID-19. In both groups, the median time under exclusive palliative care was less than one month. The exclusive palliative care survival curves did not exhibit any statistically significant difference between the groups.

Conclusion: Death due to COVID-19 did not modify the duration of exclusive palliative care among patients with advanced cancer.

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来源期刊
Einstein-Sao Paulo
Einstein-Sao Paulo MEDICINE, GENERAL & INTERNAL-
CiteScore
2.00
自引率
0.00%
发文量
210
审稿时长
38 weeks
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