流行病学数据建模的有用参数规范:理查兹曲线的复兴

IF 1.6 3区 医学 Q3 HEALTH CARE SCIENCES & SERVICES
Marco Mingione, Pierfrancesco Alaimo Di Loro, Antonello Maruotti
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引用次数: 0

摘要

我们重新提出了流行病学过程预期值的一个有用参数规范,并探讨了其统计和实证功效。理查兹曲线非常灵活,足以适应多种增长现象,包括近期的流行病和疫情爆发。这里介绍两种不同的估算方法。第一种方法基于似然最大化,在疫情仍在持续的情况下特别有用,其主要目标是在可忽略的计算运行时间内获得足够准确的估计值。第二种方法是完全贝叶斯法,允许进行更大胆的建模尝试,如纳入空间和时间依赖性,但需要更多的数据和计算资源。无论采用哪种估计方法,理查兹规范都能正确描述任何增长过程的主要特征(如增长率、峰值阶段等),从而得出合理的拟合结果,并提供良好的中短期预测。为了展示这种灵活性,我们利用公开的近期流行病数据(数据收集过程和传播模式极其不一致)以及文献中广泛使用的基准数据集展示了不同的应用,以资说明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A useful parametric specification to model epidemiological data: Revival of the Richards' curve.

A useful parametric specification for the expected value of an epidemiological process is revived, and its statistical and empirical efficacy are explored. The Richards' curve is flexible enough to adapt to several growth phenomena, including recent epidemics and outbreaks. Here, two different estimation methods are described. The first, based on likelihood maximisation, is particularly useful when the outbreak is still ongoing and the main goal is to obtain sufficiently accurate estimates in negligible computational run-time. The second is fully Bayesian and allows for more ambitious modelling attempts such as the inclusion of spatial and temporal dependence, but it requires more data and computational resources. Regardless of the estimation approach, the Richards' specification properly characterises the main features of any growth process (e.g. growth rate, peak phase etc.), leading to a reasonable fit and providing good short- to medium-term predictions. To demonstrate such flexibility, we show different applications using publicly available data on recent epidemics where the data collection processes and transmission patterns are extremely heterogeneous, as well as benchmark datasets widely used in the literature as illustrative.

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来源期刊
Statistical Methods in Medical Research
Statistical Methods in Medical Research 医学-数学与计算生物学
CiteScore
4.10
自引率
4.30%
发文量
127
审稿时长
>12 weeks
期刊介绍: Statistical Methods in Medical Research is a peer reviewed scholarly journal and is the leading vehicle for articles in all the main areas of medical statistics and an essential reference for all medical statisticians. This unique journal is devoted solely to statistics and medicine and aims to keep professionals abreast of the many powerful statistical techniques now available to the medical profession. This journal is a member of the Committee on Publication Ethics (COPE)
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