早期感染消亡的概率与病毒清除率成线性关系。

IF 2.9 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Royal Society Open Science Pub Date : 2024-10-02 eCollection Date: 2024-10-01 DOI:10.1098/rsos.240903

N Juhász, F A Bartha, S Marzban, R Han, G Röst

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引用次数: 0

摘要

我们从药物动力学的角度对随机病毒感染的消亡进行了硅学研究。我们的工作考虑了一种能提高病毒清除率的非特异性抗病毒药物，并研究了这种药物对早期感染消亡的影响。感染消亡数据由混合多尺度框架生成，该框架同时应用了连续和离散数学方法。我们论文的核心成果是观察、分析和解释病毒清除率与早期感染消亡概率之间的线性关系。这一简单关系背后的推导是通过合并不同的数学工具箱得出的。

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Probability of early infection extinction depends linearly on the virus clearance rate.

We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes.

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来源期刊

Royal Society Open Science Multidisciplinary-Multidisciplinary

CiteScore

6.00

自引率

0.00%

发文量

508

审稿时长

14 weeks

期刊介绍： Royal Society Open Science is a new open journal publishing high-quality original research across the entire range of science on the basis of objective peer-review. The journal covers the entire range of science and mathematics and will allow the Society to publish all the high-quality work it receives without the usual restrictions on scope, length or impact.