早期感染消亡的概率与病毒清除率成线性关系。

IF 2.9 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Royal Society Open Science Pub Date : 2024-10-02 eCollection Date: 2024-10-01 DOI:10.1098/rsos.240903

N Juhász, F A Bartha, S Marzban, R Han, G Röst

{"title":"早期感染消亡的概率与病毒清除率成线性关系。","authors":"N Juhász, F A Bartha, S Marzban, R Han, G Röst","doi":"10.1098/rsos.240903","DOIUrl":null,"url":null,"abstract":"We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444767/pdf/","citationCount":"0","resultStr":"{\"title\":\"Probability of early infection extinction depends linearly on the virus clearance rate.\",\"authors\":\"N Juhász, F A Bartha, S Marzban, R Han, G Röst\",\"doi\":\"10.1098/rsos.240903\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes.\",\"PeriodicalId\":21525,\"journal\":{\"name\":\"Royal Society Open Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444767/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Royal Society Open Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1098/rsos.240903\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Royal Society Open Science","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1098/rsos.240903","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

我们从药物动力学的角度对随机病毒感染的消亡进行了硅学研究。我们的工作考虑了一种能提高病毒清除率的非特异性抗病毒药物，并研究了这种药物对早期感染消亡的影响。感染消亡数据由混合多尺度框架生成，该框架同时应用了连续和离散数学方法。我们论文的核心成果是观察、分析和解释病毒清除率与早期感染消亡概率之间的线性关系。这一简单关系背后的推导是通过合并不同的数学工具箱得出的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Probability of early infection extinction depends linearly on the virus clearance rate.

We provide an in silico study of stochastic viral infection extinction from a pharmacokinetical viewpoint. Our work considers a non-specific antiviral drug that increases the virus clearance rate, and we investigate the effect of this drug on early infection extinction. Infection extinction data are generated by a hybrid multiscale framework that applies both continuous and discrete mathematical approaches. The central result of our paper is the observation, analysis and explanation of a linear relationship between the virus clearance rate and the probability of early infection extinction. The derivation behind this simple relationship is given by merging different mathematical toolboxes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Royal Society Open Science Multidisciplinary-Multidisciplinary

CiteScore

6.00

自引率

0.00%

发文量

508

审稿时长

14 weeks

期刊介绍： Royal Society Open Science is a new open journal publishing high-quality original research across the entire range of science on the basis of objective peer-review. The journal covers the entire range of science and mathematics and will allow the Society to publish all the high-quality work it receives without the usual restrictions on scope, length or impact.