紫杉醇开发战略。综述。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Justyna Żwawiak, Lucjusz Zaprutko, Anna Pawełczyk
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引用次数: 0

摘要

紫杉醇是一种具有刚性四环结构的二萜化合物,具有显著的抗肿瘤特性。Taxol 最初是从紫杉树皮中提取分离出来的。然而,由于紫杉醇的可获得性较低,研究人员不得不探索其他获取紫杉醇的技术。在过去的几年里,许多合成和半合成的方法都得到了发展。如今,许多使用细胞悬浮培养和生物转化的新型生物技术方法已开始使用并得到推广。这些过程非常有益。原因是,最终产品和工艺的产量都很高。这些方法非常独特,有助于获得大量天然化合物,而植物中通常只有少量天然化合物。此外,开发 Taxol 的一个非常重要的方面是纳米技术。使用这种方法有很多好处--保留时间延长,肿瘤组织中的药物浓度提高。这是由于纳米分子的特殊靶向性。对患者来说,最重要的是减少了全身副作用,而且不会损害健康的生物系统和组织。此外,论文还提出了应用人工智能方法的新方向。每年都有新的概念用于获取紫杉醇和开发大幅提高其生物利用率的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strategies in Taxol development. A review.

Taxol is a compound with a rigid, tetracyclic structure of diterpene, which is characterized by significant antitumor properties. Firstly, Taxol has been isolated by extraction from the bark of the yew tree. However, the low level of availability obligated the researchers' world to uncover alternative techniques of Taxol obtainment. In the last few years, many synthetic and semi-synthetic methodologies have been elaborated. Nowadays, many novel biotechnological approaches using cell suspension cultures and biotransformation are initiated and expanded. These processes are very beneficial. The reason is that both the final product and the yield of the process have high levels. Such approaches are very distinctive and they help achieve significant quantities of natural compounds, which often exist in small amounts in plants. Moreover, a very important aspect of Taxol development is nanotechnology. The use of this method has many benefits - the retention time is protracted and the concentration of a drug in tumor tissue is raised. This is due to the specific targeting of nanomolecules. What is essential for patients is that systemic side effects are reduced and the healthy biological systems and tissues do not damage. Also, the paper presents new directions with the application of Artificial Intelligence methods. Every year, new concepts are created for obtaining Taxol and developing methods to significantly increase its bioavailability.

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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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