低危和中危甲状腺乳头状癌患者甲状腺全切除术后监测中定期颈部超声检查对局部区域疾病控制的影响:倾向评分匹配研究。

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Takahiro Inaishi, Dai Takeuchi, Takahiro Ichikawa, Gai Inaguma, Atsushi Hashizume, Masaki Okazaki, Norikazu Masuda, Toyone Kikumori
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引用次数: 0

摘要

本研究旨在评估定期颈部超声检查(US)对接受甲状腺全切除术的中低风险甲状腺乳头状癌(PTC)患者术后局部疾病控制监测的影响。这项回顾性队列研究纳入了2000年1月至2016年12月期间在我院接受甲状腺全切除术和颈部中央切除术的PTC患者。患者被分为两组:体格检查(PE)组(通过PE进行随访,不定期进行US检查)和US检查组(通过PE进行随访,定期进行US检查)。两组患者均定期测量血清甲状腺球蛋白水平。采用倾向评分匹配法严格平衡重要变量,并评估两组患者的术后 10 年预后。在189名患者中,有150人经过匹配后被纳入(每组75人)。两组患者的背景特征无明显差异。中位随访期为 127.9 个月。PE组和US组的无局部复发生存率无明显差异(97.0% vs. 98.7%,P = 0.541)。PE组和US组的总生存率分别为96.7%和98.7%,无明显差异(P = 0.364)。这项研究表明,在对接受甲状腺全切除术的低危和中危PTC患者进行术后监测时,在PE基础上增加定期US检查并不会对局部控制产生明显影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of periodic neck ultrasonography on locoregional disease control in surveillance after total thyroidectomy for patients with low- and intermediate-risk papillary thyroid carcinoma: a propensity score-matched study.

This study aimed to evaluate the impact of periodic neck ultrasonography (US) on postoperative surveillance for locoregional disease control of patients with low- and intermediate-risk papillary thyroid carcinoma (PTC) who underwent total thyroidectomy. This retrospective cohort study included patients with PTC who underwent total thyroidectomy and central neck dissection at our institution between January, 2000 and December, 2016. The patients were divided into two groups: the physical examination (PE) group (follow-up by PE without periodic US) and the US group (follow-up by PE with periodic US). Serum thyroglobulin levels were measured periodically in both groups. Propensity score matching was used to rigorously balance the significant variables and assess the 10-year postoperative outcomes between the groups. Of the 189 patients, 150 were included after matching (75 in each group). There were no significant differences between the two groups in terms of background characteristics. The median follow-up period was 127.9 months. There was no significant difference in locoregional relapse-free survival between the PE and US groups (97.0 vs. 98.7%, p = 0.541). The overall survival was 96.7% and 98.7% in the PE and US groups, respectively, with no significant difference (p = 0.364). This study demonstrated that the addition of periodic US to PE for postoperative surveillance of patients with low- and intermediate-risk PTC who underwent total thyroidectomy did not significantly affect locoregional control.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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